10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound в (C) Km values with compounds A and B are the same (D) The maximum reaction rate with com- pound A is greater than that with com- pound B (E) The maximum reaction rate with com- pound B is greater than that with com- pound A|

10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-HT1B), a G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound в (C) Km values with compounds A and B are the same (D) The maximum reaction rate with com- pound A is greater than that with com- pound B (E) The maximum reaction rate with com- pound B is greater than that with com- pound A|

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Description: 10. A scientist working in a research laboratory hasbeen examining different agonists of serotoninreceptor 1B (5-HT1B), a G-protein-coupled re-ceptor. Compound A has a much higher affin-ity for 5-HT1B than compound B. Both com-pounds have a higher a

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...

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10. A scientist working in a research laboratory has been examining different agonists of serotonin receptor 1B (5-НT1B), а G-protein-coupled re- ceptor. Compound A has a much higher affin- ity for 5-HT1B than compound B. Both com- pounds have a higher affinity for the receptor than serotonin. Which of the following de- scribes the relationship between compound A and compound B when considering the guan- ine-nucleotide exchange activity of 5-HT1B? (A) Km for the exchange reaction with com- pound A is higher than that with com- pound B (B) Km for the exchange reaction with com- pound A is lower than that with compound (C) Km values with compounds A and B
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