1. For each of the reactions below, give the structure(s) of the product(s), and be sure to indicate relative stereochemistry where appropriate. If more than one product is formed, indicate if they will be formed in equal amounts, or if one is expected to be the major product. If no reaction is expected to occur under the indicated conditions, then write “no reaction" or N.R. and explain why you would expect nothing to occur. 1. PPH3 2. KOTBU а. Br 3. На, Pа/C b. H3C H3C- 1. O3 2. Me2S 3. H2NNH2, КОН, Д с. H* (-H2O] H3C „CH3 N. H
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![1. For each of the reactions below, give the structure(s) of the product(s), and be sure to indicate
relative stereochemistry where appropriate. If more than one product is formed, indicate if they
will be formed in equal amounts, or if one is expected to be the major product. If no reaction is
expected to occur under the indicated conditions, then write “no reaction" or N.R. and explain why
you would expect nothing to occur.
1. PPH3
2. KOTBU
а.
Br
3. На, Pd/C
b.
H3C
H3C-
1. O3
2. МMe2S
3. H2NNH2,
КОН, Д
c.
H* [-H2O]
H3C.
CH3
N'
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