Answered: [1] (R)-CBS reagent Nal CH3NH2 [1] NaH…

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Chemistry

[1] (R)-CBS reagent Nal CH3NH2 [1] NaH A B duloxetine [2] H20 [2]

Chemistry & Chemical Reactivity

9th Edition

ISBN:9781133949640

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter24: Biochemistry

Section24.3: Nucleic Acids

Problem 1RC: 1. Which breaks down more quickly in an aqueous solution? DNA RNA

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Question

Several steps in the synthesis of optically active duloxetine, an
antidepressant sold under the trade name Cymbalta, are shown. Identify
the structure of intermediates A–C and the final product duloxetine,
including stereochemistry, in this reaction sequence.

[1] (R)-CBS reagent
Nal
CH3NH2
[1] NaH
A
B
duloxetine
[2] H20
[2]

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