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- The plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) are shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data is shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain how you know this from the profiles? (B) Is this a problem for cough suppression? Explain. -CH HO Codeine COD 10 000 1000 C6G COD 100 M3G M6G NM 10 M 10 20 30 0 10 20 30 Plasma concentration (nmol I-)Which of the following is incorrect about blood glucose test interpretation A) fasting plasma glucose 6.1-6.8 defined as having IGT and should probably be screened again after a year or so. B) 2 results>7mmmol/l defined as having diabetes C) fasting plasma glucose >6mmol, recall for further test. D) fasting or random plasma glucose, on one reading of <11.1mmol/l is diagnostic of diabetes1000 Tablets 48, Kandivli Ind Estate, Mumbai 400 067, India by: Ipca Laboratories Limited Jacksonville, FL 32257 USA Ranbaxy Pharmaceuticals Inc. Manufactured for Rx only LOT: EXP: 100 mg TABLETS, USP ALLOPURINOL N Each scored tablet contains: Allopurinol, USP........100 mg Store at 20° to 25°C (68° to 77° F) [See USP Controlled Room Temperature]. Dispense in tight, light-resistant container as defined in the USP. USUAL DOSE: One tablet daily. For indications, dosage, precautions, etc., see accompanying package insert. Code: DNH/DRUGS/NH/170 3 633041153910 NDC 63304-539-10 Non varnish area R RANBAXY LBZTL6 0311 Expiration date Prescription warning Total amount in vial, packet, box Usual adult dose Dosage strength Drug form Lot number (control number) National Drug Code (N D C) # Manufacturer Brand name Generic name
- One such neurotoxin, Sarin (chemical name: propan-2-yl methylphosphonofluoridate) is considered a weapon of mass destruction by the United Nations by virtue of its ability to kill with great efficiency in very low concentrations. a. Where does Sarin have its effect (what is/are its target) and describe the mechanism of action of Sarin (how does it kill)? b. Describe the physical symptoms observed in those stricken with Sarin that are consistent with this mechanism of action. Include flaccid/tonic paralysis, as applicable.rug-B has an elimination half-life of 9 hours, an absorption half-life of 20 minutes and linear harmacokinetics. In a patient, the plasma concentration five hours from the administration of two 60 mg cablets of the drug is 8 ug/mL. What would you expect to be the plasma concentration five hours from the administration of one 60 mg tablets? 1 ug/mL Answer 1-1What is the approximate rate of change of A340 measured? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 30 ml of the ADH solution was tested in the same way (i.e. half the amount of protein) ? i.e. ΔA340 / min = __________ What rate of change of A340 would you predict if 60 ml of a 0.5 μM ADH solution was tested in the same way? i.e. ΔA340 / min = __________ As well as writing your answers, explain your reasoning.
- How much active ingredient in 20 cc of a 15% solution? You have 1:1000 concentration of epinephrine. How many mLs do you need to draw up if you want to give 45 mg of the drug? (I need help please :)What are the advantages and disadvantages of HCR-20 for use in clinical services? I need this to be detailed and thoroughly explained with examples and support from research evidence. Thank you :) 4An experiment was carried out to measure the reaction rate of hydrolysis of acetylcholme (substrate) with serum enzymes (Eadie, 1949). In the experiment, two experiments were conducted, namely experiment 1 without using a prostigmine inhibitor and experiment 2 using a prostigmine inhibitor at 1.5 x 10^-7 mol/l. the data obtained are: a. Is prostigmine competitive or noncompetitive inhibitor? b. determine the value of km and rmax for the two experiments, compare
- Your 67 YO 195lb, 5ft 10in male patient diagnosed with testicular cancer has been prescribed ifosfamide 1200mg/M2/day IV for 5 days. You calculate the BSA using the mosteller method as being 2.09m2. Ifosfamide is available in 60mL vials contianing 3g of drug. a) How many mL will you administer each day?In 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.1) Draw a chromatogram depicting separation of proteins 1, 2, and 3 (protein #1, mw 30,000, protein #2, mw 60,000, and protein #3, mw 90,000). b)Indicate on the chromatogram in (a) where insulin would elute. Would insulin have total accessibility, some accessibility or no accessibility to the particle pores on this column? c)Referring to the size exclusion chromatogram in (a), indicate on the chromatogram where you would expect a molecule with a size of 40,000 to elute. Would you expect the molecule to be well resolved, somewhat resolved, or not resolved from the peak for protein #1?