. The renal clearances and plasma protein binding of three drugs in a 70 kg adult are as follows: Drug Renal Clearance (ml/min) % bound to plasma proteins 50 Theophylline Phenytoin Cefonicid 10 0.15 90 20 98 If GFR is 120 ml/min and urine flow is 1.5 ml/min, what is the likely involvement of filtration, secretion and reabsorption in the renal excretion of each of these drugs?

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3. The renal clearances and plasma protein binding of three drugs in a 70 kg adult are as follows:
Renal Clearance (ml/min) % bound to plasma proteins
Drug
Theophylline
Phenytoin
50
90
Cefonicid
98
10
0.15
20
If GFR is 120 ml/min and urine flow is 1.5 ml/min, what is the likely involvement of filtration,
secretion and reabsorption in the renal excretion of each of these drugs?
Answers: 1a. 0.114, c. 51.8 L/hr, d. 5.4 L/hr, e. 46.4 L/hr, f. 67.2 L/hr, g. 454 L/hr
2a. theophylline filtered and reabsorbed; phenytoin filtered and reabsorbed; cefonicid filtered and secreted
Transcribed Image Text:3. The renal clearances and plasma protein binding of three drugs in a 70 kg adult are as follows: Renal Clearance (ml/min) % bound to plasma proteins Drug Theophylline Phenytoin 50 90 Cefonicid 98 10 0.15 20 If GFR is 120 ml/min and urine flow is 1.5 ml/min, what is the likely involvement of filtration, secretion and reabsorption in the renal excretion of each of these drugs? Answers: 1a. 0.114, c. 51.8 L/hr, d. 5.4 L/hr, e. 46.4 L/hr, f. 67.2 L/hr, g. 454 L/hr 2a. theophylline filtered and reabsorbed; phenytoin filtered and reabsorbed; cefonicid filtered and secreted
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