. Separating Glycated Hb From Normal Hb (Integrates with Chapters 5and 6.) Human hemoglobin can react with sugars in the blood(usually glucose) to form covalent adducts. The a-amino groups ofN-terminal valine in the Hb b-subunits react with the C-1 (aldehyde)carbons of monosaccharides to form aldimine adducts, whichrearrange to form very stable ketoamine products. Quantitation ofthis “glycated hemoglobin” is important clinically, especially fordiabetic individuals. Suggest at least three methods by which glycatedHb (also referred to as HbA1c) could be separated from normal Hband quantitated
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
. Separating Glycated Hb From Normal Hb (Integrates with Chapters 5
and 6.) Human hemoglobin can react with sugars in the blood
(usually glucose) to form covalent adducts. The a-amino groups of
N-terminal valine in the Hb b-subunits react with the C-1 (
carbons of monosaccharides to form aldimine adducts, which
rearrange to form very stable ketoamine products. Quantitation of
this “glycated hemoglobin” is important clinically, especially for
diabetic individuals. Suggest at least three methods by which glycated
Hb (also referred to as HbA1c) could be separated from normal Hb
and quantitated
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