The Smallpox Vaccine

The history of vaccinations begin with Edward Jenner, the country doctor from Gloucestershire who found, growing on cows, a nearly harmless virus the protected people from smallpox. Jenner’s vaccine was safer, more reliable, and more durable than variolation, and it is still the only vaccine to have eliminated its reason for being-in 1980, when the World Health Organization (WHO) declared the disease extinct. For nearly a century and a half, smallpox was the only vaccine routinely administered, and it saved millions of lives . But the controversy that marked the return of the vaccine, amid bioterrorism hysteria in 2002, was only the latest twist in the remarkable, mysterious life of vaccines.

Over many of years the world has faced problems concerning health. Many scientists and health experts have worked together to better our nation 's health care. English Physician and Scientist Edward Jenner, a small country doctor, who is well known around the world for his innovative contribution to immunization and the ultimate eradication of smallpox. (2005, Baylor University Medical Center.) It is believed that smallpox appeared around 10,000 B.C. Smallpox was introduced to Europe sometime between the fifth and seventh centuries and was frequently epidemic during the Middle Ages. Edward Jenner was born on May 17, 1749, in Berkeley, Gloucestershire. During his early school years, Edward developed a strong interest in science and nature that continued throughout his life. Jenner’s interest in natural history and animal biology sharpened his medical understanding of the role of human-animal trans-species boundaries in disease transmission. He experienced the proverbial “Eureka”-like moment sometime during the 1770s. At age 13 he was apprenticed to a country surgeon and apothecary in Sodbury, near Bistol. The record shows that it was there Jenner heard a dairymaid say, " I shall never have smallpox for I have had cowpox. I shall never have an ugly pockmarked face." While Jenner 's interest in the effects of cowpox began during his apprenticeshire with George Harwickle, it wasn 't until 1796 before he made the first step in a long process of smallpox would be exposed. Jenner

Vaccinations have been actively used for over 200 years now and have been effective for over 200 years as well. Western medicine’s introduction to the practice is said to have occurred within the eighteenth century, when a traveling British aristocrat, Lady Mary Wortley Montagu, reported her observations of Turkish children being injected with pus from smallpox victims. Although this practice seemed quite harsh, most of these children would contract only a mild version of the illness. In return, these recipients would retain a lifelong immunity to this terrible disease (World of Microbiology & Immunology). Similarly, in the United States, a Puritan minister by the name of Cotton Mather learned about inoculation from his African slave, Onesimus. Onesimus claimed that he was inoculated with smallpox pus and never caught the tragic disease (Williams). This type of medicinal treatment was initially rejected by most Western practitioners. They felt it was a dangerous and barbarous practice, but vaccination gained a tremendous amount of support at the turn of the nineteenth century when English physician Edward Jenner created a new smallpox vaccine derived from the relatively mild cowpox virus (Riedel). There’s no doubt that history has shown the positive outcomes of immunization and continued to show them as technology and medicine progressed.

Edward Jenner was a scientist in the mid 1700's until the early 1800's who is credited as the Father of Immunology. His experiments with vaccines made it possible to nearly wipe out the threat of death from the smallpox disease, a disease that killed many people and had no cure. Although things worked out for Jenner, he would not have passed the World Health Organization International Ethical Guidelines for Biomedical Research Involving Human Subjects nor the Nuremburg Code.

Edward Jenner and the Discovery of Vaccines Edward Jenner (1749-1823) trained in London, under John Hunter, and was an army surgeon for a period of time. After that, he spent his whole career as a country doctor in his home county, Gloucestershire (West of England). His research was based on careful case studies and clinical observation more than a hundred years before scientists could explain what viruses and diseases actually were. His innovative new method was successful to such an extent that by 1840 the British government had banned alternative preventive treatments against smallpox. [IMAGE]

It was during this era that Edward Jenner invented a vaccine to prevent smallpox by inoculating a healthy eight-year old boy with cowpox;

However, Jenner’s invention became a common practice only a few years after he released it to the public, and according to The Hutchinson Unabridged Encyclopedia, “By 1890 smallpox had virtually been eradicated from Britain.” (“Jenner, Edward (1749-1823)”) From the information about the first vaccination, we can see that vaccinations have been proven to eliminate deadly diseases, whether they receive opposition or not. Without immunizations, we would be overcome with diseases, such as smallpox, polio, and measles.

Currently the only existing forms of smallpox are in two secure laboratories; the CDC facility in Atlanta and Russian State Research Centre for Virology and Biotechnology in Koltsovo. These samples were scheduled to be destroyed in 1993 but there was and still is much debate about what should happen to them.

Jenner’s discovery of the link between cowpox and smallpox was significant to the development of a vaccine for smallpox. However, it can be argued that Jenner and his discovery were not enough on their own to bring medical progress. The factors Scientific thinking, Government Communication and Changing attitudes played a major and important role to bring medical progress.

Armed with opposable thumbs and high-functioning frontal lobes, humans have historically battled disease, including the “the speckled monster”; smallpox. Known as a highly contagious virus, smallpox has been around since 10,000 B.C., and its plagues are responsible for causing millions of deaths. There was no knowledge of how to treat or prevent this disease from spreading until the idea of taking samples of dead smallpox cells and injecting them into a human was proven to build immunity. Over time, the treatment was perfected and has changed medical history by introducing the idea of the vaccine. Smallpox vaccinations eventually became mandated, and in 1979, smallpox was declared to be the first disease to ever be completely eradicated from

The earliest case of smallpox according to a journal published in the US National Library of Medicine titled, “Edward Jenner and the History of Smallpox and Vaccination” was recorded as early as 1122 BC. (Riedel “Smallpox the Origin of a Disease”). Mankind’s triumph over this horrible disease was initiated by an English doctor named Edward Jenner. Through observations and experimentation, Jenner would create a procedure now known as vaccination. (Riedel “Edward Jenner”). During the next two centuries, vaccinations would be used worldwide to stop the spread of small pox. After the successful worldwide vaccination campaign led by the World Health Organization, small pox was eradicated worldwide in 1980. As a result of the eradication of smallpox according

This means that scientists could still conduct experiments in regards to smallpox vaccination and treatment without the current living samples. At the same time however, this means that anybody with sufficient materials and knowledge could potentially make the smallpox virus through use of the publicly available genomes, which leaves the general public equally endangered from synthesised strains of the virus (Randerson, 2006). So even if the official samples of smallpox were discontinued, it would not necessarily ensure safety from the

According to Dan Epstein of the World Health Organization (WHO), a pandemic is “a global epidemic- an epidemic that spreads to more than one continent (WHO.int)”. It often begins an animal infection that spreads to humans and proceeds to infect a larger population worldwide. Often, the infectious disease emerges suddenly and spreads rapidly, making it difficult to develop a vaccine in enough time to prevent high morbidly and mortality rates (Journal of Infectious Diseases, 2009). Despite their slow production and high cost of development, vaccines have been called the “greatest success story in public health” (WHO.int). Edward Jenner first introduced the smallpox vaccine in the later 19th century and the vaccine successfully eliminated smallpox

Today most children in the United States live a much healthier life and parents live with much less anxiety due to vaccinations. More than 200 years ago, Edward Jenner conducted an experiment that would be one of the most astounding breakthroughs in medical history. Jenner noticed that milkmaids didn’t catch the smallpox, a disease rampant across the English countryside. He reasoned that the blisters on the milkmaid’s hand must contain something that was protective. He tested his theory by taking fluid from a blister on the wrist of a milkmaid and inoculating it into the arm of a local laborer’s son (Offit and

According to my research, in 1796 Dr. Edward Jenner developed a vaccine for smallpox disease however during this time only cows were infected. This vaccine came from the cowpox virus. In 1809, the state of Massachusetts became the first to mandate the smallpox vaccinations then in 1879 a group of Anti-Vaccination of America was formed and their belief is that no one should be forced to vaccination. They believed that the vaccine was spreading the disease instead of preventing it. In 1986