Drug Dependence And Addiction : Drugs

The most commonly abused substances are Nicotine, Inhalants, Alcohol, Cocaine, Amphetamines, Prescription medications, Heroin, Ecstasy and Marijuana. 1a(National Institute on Drug Abuse, 2011) Initially, a person may find themselves using substances voluntarily and with confidence that they will be able to dictate their personal use. However, over the period of time that drug use is repeated, changes are taking place throughout the brain, whether it is functionally

Brain chemistry is a detailed system that helps the brain to interact with the chemicals that moves important around the brain. Brain chemistry changes depending on what substance or how much of the substance is used. These changes can indicate signs of the beginning of an addiction over time if the drug use begins to get worst it can lead to dramatic changes in the brains over all chemistry. This example supports the theory of brain change ”‘when we elevated levels of ΔFosB in the NAc, the mice exhibited behaviors that are considered reliable indicators that exposing people to the same conditions would cause addiction: They showed more sensitivity to the drug (responded to doses one-third those required to produce a response in normal animals), self-administered more drug, and displayed greater drive (or craving) for cocaine (they worked two to three times as hard to get the drug) ().” The opposing side stated this as their disagreement “human psychology is simply the reflection of human neurophysiology. Thus, for instance, although the authors claim that their account of addiction is relatively 'skeptical,' and has less explanatory power than that of their opponents, they nevertheless seem to accept at least the possibility of a complete account, which will only come about as a result of 'further advances in biological and psychological science (Foxcroft, L. J.

To understand addiction further, it is important to look at how drugs have neurological effects in a human body. Drugs can be ingested in various ways; while some are taken orally, some are smoked (cannabis) while others are injected directly into the blood stream (Heroin). Once in the body, they mainly affect the reward pathway in the brain, known as the dopaminergic pathway, which in turn gives pleasure. Even though all drugs affect the reward and motivation pathways in the brain, their speed depends on the way the drug has been consumed. Over constant use of drugs, the cognitive functions are impaired as the effects become more prominent in learning, memory

This research paper will evaluate the biological aspects of addictive substance or behavior and how it affects the brain and organs. Biological aspects include dopamine levels that are replaced in the brain due to the reward system being overtaken and the absorption rate of the drug once it is ingested will be discussed. The biological aspects are extensive and permanent if the individual does not get the help they need. Furthermore the clinical issues of addictive substance or behavior will be discussed along with medical treatments and ethical issues. This includes treatments such as counseling

According to the biological perspective, drug use may start off as casual, but through continued use, it produces changes in the brain that influences the onset and maintenance of drug addiction. (Horvath et al., 2013). Drugs have their most prominent effects on the function of neurotransmitters. Almost all major drugs of abuse activate the reward system and cause a flood in the levels of dopamine which is a neurotransmitter that is involved in pleasure. As a result, not only do people learn to associate drug use with pleasure, but the brain also starts to reduce its own natural dopamine production in adjustment to the levels of dopamine produced by the drugs. This is called tolerance, and the consequences of tolerance are highly influential

When activated at normal levels, this system rewards our natural behaviors. Overstimulating the system with drugs, however, produces euphoric effects, which strongly reinforce the behavior of drug use—teaching the user to repeat it. (1)

Across all addictions, there is a central theory as to how such an addiction can occur. The common mechanism of all addictive substances is the activation of the brain’s “reward system”, made up of dopaminergic neurons of the midbrain and their extensions to the limbic system (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272277/). This system is normally used in advancing evolutionary fitness promoting activity, such as sex, food, or social interactions (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272277/). In such normal natural behaviors, the reward system activity is relatively brief and weak. However, addictive substances abuse the system’s circuitry, causing

Drugs have been around for a very long time. They are used for a variety of reasons. Some of these reasons include relaxation, socialization, curiosity, stress relief, or a form of escapism. However, most people don’t know the threats and danger that it can cause to the body. In this paper, we are going to examine the changes that happen inside the brain due to the effects of different drugs. We will look closely at how drugs such as hallucinogens, ecstasy, cocaine, heroin, and cannabis affect an individual psychologically. I will explain the origin of the drugs, how a person feels while on the drug, how the drugs

Substance addiction can hugely impact on a person’s thinking, functioning and behaviour. Whilst depressant drugs such as alcohol and opioids slow down your central nervous system (CNS), stimulants such as cocaine or amphetamine increase the activity of the CNS, leading to higher blood pressure, heart rate and increased alertness. Repeated abuse of the substance leads to tolerance and withdrawal, in turn this leads to the user showing signs of irrational behaviour. Another form of substance abuse is hallucinogens; they can cause powerful changes in sensory perceptions. It works by binding to the serotonin receptors, these neurons control visual information and emotions, and this can lead to various effects on the user. Neurobiology can help us understand the reasons for addiction and the effects they have on us. Groman and Jentsch (2012) discuss key issues of differentiating the causes and consequences of addiction through neuroimaging and behavioural research on monkeys, they found that the dysfunction of the dopamine

An individual’s behavior and emotion becomes chemically altered often resulting in dependency, aggression, onset of diseases and poor judgement. This poses a dangerous threat to the neurotransmitters since they have multiple jobs in different parts of the brain. Drugs of abuse are able to exert influence over the brain reward pathway either by directly influencing the action of dopamine within the system, or by altering the activity of other neurotransmitters that exert a modulatory influence over this pathway. These drugs are often powerful and have been known to trigger schizophrenic behavior and can also cause a person to cease breathing, for example hallucinogens such as LSD, mescaline, and psilocybin are able to artificially stimulate the serotonin receptor (Sapolsky, 2005).

The drug Cocaine alters chemical levels in the brain which can lead the user to have the ‘feel good’ factor.

Cocaine, on the other hand, has been found to have a profound effect on increased dopamine activity. Kennedy & Hanbauer (1983; cited in Karch, 2007) found a strong correlation between cocaine binding and the inhibition of dopamine uptake, and therefore proposed that dopamine transporters are binding sites for cocaine. Such research, which correlates strong reinforcing properties of cocaine with inhibition of dopamine transporters, suggests that cocaine has a more significant affect upon dopamine, than than it has upon serotonin and noradrenaline. The excessive role of dopamine can explain the high degree of pleasure that users of cocaine experience, as well as depression and cravings, which follow.

The complexity of the human brain creates mystery when determining the influence of neurophysiological factors and their role in the process of addiction. There is a proposed relationship between drug addiction and the mesolimbic dopamine system, with the mesolimbic pathway from the ventral tegmental area to the nucleus accumbens considered the ‘reward centre’ of the human brain (Alcohol Rehab, 2011). A release of dopamine is necessary for ‘reward’ which is hypothesised to initiate the addiction cycle by providing positive reinforcement for drug self-administration (Feltenstein & See, 2009). Methamphetamine triggers the release of dopamine from synaptic vesicles which flood the synaptic cleft activating feelings of euphoria, well-being

“The overstimulation of this reward system, which normally responds to natural behaviors linked to survival (eating, spending time with loved ones, etc.), produces euphoric effects in response to psychoactive drugs. This reaction sets in motion a reinforcing pattern that “teaches” people to repeat the rewarding behavior of abusing drugs ”(“Understanding Drug Abuse). Using addictive drugs floods the limbic brain with dopamine, taking it up to as much as five or ten times the normal level. A person with elevated dopamine levels now has a brain that begins to associate the substance with an outside neurochemical reward (“Your Brain on Drugs”). As a person continues to abuse drugs, the brain adapts to the overwhelming surges in dopamine by producing less dopamine or by reducing the number of dopamine receptors in the reward circuit. The result is a lessening of dopamine’s impact on the reward circuit, which reduces the abuser’s ability to enjoy the drugs, as well as the events in life that previously brought pleasure. The decrease in normal dopamine levels encourages the addict to keep abusing drugs in an attempt to bring the dopamine function back to normal, except now larger amounts of the drug are required to achieve the same dopamine high, an effect known as tolerance (“Understanding Drug Abuse ). That is what leads to the state of addiction, which leaves the person in a cycle of craving, using, withdrawal, and relapse.

Have you ever dealt with the effects of drug addict? A drug is a person who is addicted to drugs or alcohol, which has a psychological effect when ingested or otherwise introduced into the body. The effects of drug use can vary depending on the person. According to “Causes and types of narcotic addiction: A Psychosocial View” in the Psychiatric Quarterly it says, “The causes of drugs stem from the manner of which you were introduced to it whether it be by abnormal curiosity, chance encounters with addicts and narcotic peddlers, or prolonged illness” (Ausubel). The effects of drugs can be have different effects on everyone differently depending if its for pleasure or for relieving pain Most of the effects of drugs occur in the brain, where it increases the level of dopamine at a specific site possibly giving the addict the pleasure they were feigning for (Robbins). As a child I didn’t know much about drugs except for what your parents and teachers at school tell you which is, “Just Say No.”