Antibiotics and Their Influence on the Creation of Superbugs
Shawna R. Papach
State College of Florida
ENC: 1101:11985
11/13/2016
Abstract
Antibiotics have been a very important means for someone to feel better. Since the discovery of Penicillin in 1928, antibiotics have saved many countless lives that otherwise wouldn’t be saved. The real threat in the world today is the rapid spreading of antibiotic resistant diseases. To address this worldwide problem the National Action Plan for Combating Antibiotic-Resistant Bacteria was developed and issued by President Barack Obama on September 18, 2014. This plan lists five goals to slow the progression of resistant bacteria. These goals work as a guide actions of the U.S government and public health agencies around the world to address this big concern to the world’s safety.
Antibiotics and Their Influence on the Creation of Superbugs Antibiotic resistant infections are on the rise in the United States, and this rise can be directly attributed to the over-prescription of antibiotics by healthcare professionals. Even with the many advances in the world today when it comes to antibiotics and treating infections, antibiotic resistant diseases are on the rise. With the diminished ability to destroy the growth of bacteria, the less we are able to get the quick fix that we believe is achieved with the use of antibiotics. Resistance compromises the benefits that we currently have to treat anything from pneumonias to antibiotics given
A couple times a year local and national mass media put the spotlight on problems connected to antibiotic overuse. Some people consider those problems to be real and serious, and others think that the discussed topics are nothing more than new “fashionable” subjects to talk about, distracting people from “real” problems, such as climbing gas prices or war expenses. Meanwhile, antibiotic overuse continues as a common practice among US doctors and agribusinesses for the last 20 years. The practice of antibiotic overuse has put patient’s health at risk, contributed to antibiotic resistance and increased bacterial mutation to a new, stronger level; as well as it hitting the economy with new costly expenses in health care. It is time to stop
Throughout my life, adults have insisted the use of antibiotics to fight against the most inconsequential illnesses, whether it’s the cold or the flu. However, neither illness is due to invasion of bacteria. This misuse can lead to antibiotic resistance, also known as antimicrobial resistance(AMR), currently one of the central issues facing the public health system. While the process for antibiotic resistance occurs naturally through the process of adaptation, the mismanagement of antibiotic resources has accelerated the rate at which the bacteria adapt. The occurrence of this misinformation isn’t limited to a few adults: even some of my peers suggest taking antibiotics when faced with the flu. This leads to asking whether AMR is truly a problem and are present regulations enough to combat the issue.
With all of our modern advances, it seems somewhat strange that chronic health problems have become so commonplace. When antibiotics were discovered, they predicted the end of disease. Instead, we now have a world full of frightening antibiotic resistant infections.
A current predicament in the field of science is antibiotic resistance against superbugs.Though fighting against superbugs; which can be defined as a strain of bacteria unable to be killed using multiple antibiotics, is now a large problem, in the past it was not. The evolution of resistance in bacteria due to antibiotic abuse and lack of product development has brought upon us once again the fear of a pre-antibiotic era; one where simple, once easily defeated infections could kill. Already, infectious diseases are the 3rd leading cause of death in the US and the 2nd across the entire world, and drug resistant superbugs send 2 million Americans to hospitals every year; killing 23,000 of those people. And any bacterium can quickly and easily become multidrug resistant, the leading cause of this being antibiotic misuse in both humans and animals.( "Clinical Infectious Diseases." The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America. UCLA Medical School. Web. 27 Mar. 2016.)
Dr. Martin Blaser, author of Missing Microbes: How the Overuse of Antibiotics is Fueling Our Modern Plagues, paints antibiotics as a negative force in the world that causes disease. Dr. Blaser has studied the role of bacteria in human disease for more than thirty years at Vanderbilt University, and has experience as the director of the Human Microbiome Project at New York University. He also works with the National Institute of Health on infectious diseases. Meanwhile, Dr. David Shlaes, author of Antibiotics: The Perfect Storm, focuses on the drugs’ ability to cure disease. Dr. Shlaes has worked for 30 years in anti-infective academia, industry, and consulting. He served as Professor of Medicine at Case Western Reserve University for five years, and then moved to industry, where he became vice president of Infectious Diseases at Wyeth Research. Later, he took a position as executive vice president of research and development at Idenix Pharmaceuticals in Cambridge, Massachusetts, and formed his own consulting company. He now works predominantly with biotech companies and venture capital firms in their evaluation of anti-infective companies. While they take different approaches, the two doctors concur that antibiotic resistance is a major problem and that society needs to find ways to slow it down. One way to slow down the spread of resistant bacteria is finding ways to ensure
Overtime, antibiotics have been favorable as well as negligent to society. Antibiotic usage is helpful to society because it kills and fights off bacteria in both humans and animals. With an increase in antibiotic usage, these bacteria have become resistant to certain drugs which reduce the chance of the bacteria being killed off and result in bacteria multiplying, causing increased harm to the infected. According to Centers for Disease Control and Prevention (CDC, 2013), each year in the United States at least 2 million people become infected with bacteria that are resistant to antibiotics and at least 23,000 people die each year as a result to these infections. Although multiple bacteria are antibiotic resistant, and those numbers will continue to rise, antibiotics should remain a staple in the treatment of diseases, as opposed to abandoning their use which will cause an increase in the prevalence of bacterial infections.
Antibiotic-resistant microbes infect more than two million Americans and kill over 100,000 each year. These numbers will continue to grow unless we make a drastic effort to curtail them. The necessary response is threefold and includes legislation, awareness, and activism. I will address all of these.
Antibiotics have been taking over the United States. Antibiotics have become resistant. Americans can no longer not focus on this topic. It has taken over. The medical community has made the public aware of the causes and possible solutions of this health emergency, and its devastating impact..
Antibiotic resistance occurs when bacteria changes and reduces the effectiveness of an antibiotic. Using the wrong antibiotic for disease-causing bacteria can end in an overuse of that antibiotic and promotes antibiotic-resistance. Information gathered by the Bash the Bug Project can be used to find the correct antibiotic to fight certain disease-causing bacteria. Therefore, limiting bacteria’s opportunity to develop antibiotic-resistance. This is important to the general public because antibiotic-resistant bacterium is more difficult to kill, requires a more expensive treatment, and is given more of an opportunity to spread. While antibiotic resistance cannot be completely stopped, prescribing the correct antibiotic can greatly slow the spread of antibiotic resistance infections. The Bash the Bug project will then allow more time for newer drugs that can fight antibiotic resistant bacteria that are already in
The misuse of antibiotics has the potential to set society back in time to the dark ages. It is time to end the careless use of these valuable antimicrobial that so many take for granted. Antibiotic resistance continues to expand and evolve and solutions to this epidemic need to implemented. By establishing stewardships, educational programs, and restrictions it teaches the severity of this issue and action that must be taken in order to decrease resistance. Antibiotic resistance is a multifactorial issue. Introducing preventative measures in hospitals will be most effective in reducing resistance, as well as eliminating the trend of misusing antibiotics.
A huge advancement was made in the world of medicine when antibiotics were first invented. Suddenly, deadly diseases such as Staphylococcus could be cured. (Tan, 2014) Before antibiotic discovery in 1928, and their prescription in the late 1930’s, Streptococcus pyogenes caused 50% of post-birth deaths, and was a major cause of death in burn victims. Staphylococcus aureus killed 80% of people with infected wounds, and tuberculosis and pneumonia ran rampant within the population. Through the use of antibiotics, these diseases could be easily treated. Between 1944 and 1972, human life expectancy leaped by eight years, primarily accredited to antibiotics; and the number of people dying due to bacterial infection dramatically fell. (Australian Broadcasting Corporation, 1999) Therefore, antibiotics are beneficial as they are able to save lives, and treat various types of bacterial diseases. In addition they are easily administered - they may simply be taken orally, or injected. They are also cost-effective, and have few side effects. Moreover, the cost of antibiotic regulation, public ignorance of the threat, and adherence to routine are major factors preventing regulation laws to be put in place. (Krans,
Before antibiotics were discovered, bacterial infections like strep throat and meningitis were untreatable and often deadly. Things that seem easily treatable to us now, like an ear infection, could mean a death sentence to those with weak immune systems, such as the very young or the elderly. Antibiotics were first discovered in the form of penicillin by Alexander Fleming in 1928, but its true power wasn’t recognized until the 1940s after more medical testing was conducted. Once the commercialization of antibiotics began, it was declared a ‘miracle drug’ and its use skyrocketed to the number of prescriptions we see today, about 150 million a year (“History of Antibiotics”). Antibiotics have saved millions of lives, and without a doubt have improved the quality of life of many people around the world, but unfortunately, not everyone uses them correctly. Overuse of prescription antibiotics is becoming increasingly common, with some people hoarding leftover pills and needlessly taking
Antibiotic development is one of the modern marvels of medicine. This is the first external tool that people have to fight against bacterial infections. The first drug developed was Penicillin. This medication is so effective that it is still used today. From its structure, every other antibacterial drug was developed. Today, there are hundreds of options available for treating infections. Unfortunately, this has had significant ramifications on the development of resistance to these medications. As the infections continue to learn and evolve, it is important that people educate themselves on what this means and the impacts it has.
The overuse of antibiotics has been a problem for well over a decade. This misuse leads to many nonvisible problems arising within the human population. As the use of antibiotics increases, the number of antibiotic resistant bacteria also increases. When bacteria become resistant to an antibiotic, another antibiotic must be used to try and kill it and the cycle becomes vicious. Michael Martin, Sapna Thottathil, and Thomas Newman stated that antimicrobial resistance is, “an increasingly serious threat to global public health that requires action across all government sectors and society” (2409).
According the World Health Organization (WHO), antibiotic resistance is one of the world’s greatest health threats to date (Haddox, 2013). In the article, The Health Threat of Antibiotic Resistance, Gail Haddox (2013) discusses the danger antibiotic resistance poses in today’s society and strategies to prevent the expansion of antibiotic resistance. In Europe alone, an estimated 25,000 deaths have been attributed to multi-resistant infections (Haddox, 2013). Common infections are now harder to treat due to the increased resistance to antibiotics across the world, in fact some are becoming untreatable. Antibiotics should be treated like oil, a non-renewable resource (Haddox, 2013).