2Analysis of Articles

.docx

School

Florida Institute of Technology *

*We aren’t endorsed by this school

Course

MISC

Subject

Medicine

Date

Apr 3, 2024

Type

docx

Pages

8

Uploaded by Tiffani82682 on coursehero.com

1 Effectiveness of Esketamine in Treating Depression: Analysis of Articles Name University PSYCH Prof. January 2024
2 Effectiveness of Esketamine in Treating Depression: Analysis of Articles 1.0. Introduction 1.1. Topic Areas In 2019, the FDA approved Esketamine, derived from a potential anaesthetic, Ketamine, to treat treatment-resistant depression (TRD) among adults. Unlike conventional anti-depressants that increase the levels of naturally occurring chemicals in the brain, Esketamine works by optimizing the synapse's plasticity by modulating glutamate (Vasiliu, 2023). This paper aims to scan the existing research on the effectiveness of Esketamine in treating depression, focusing on five articles. 1.2. Search Strategy The articles were located in four reputed databases: PubMed, Google Scholar, National Library of Medicine, and ProQuest. The articles were located by mainly relying on the following key phrases or search queries: "Effectiveness of Esketamine in treating depression” "Effects of Esketamine on patients with depression” “Results of using Esketamine for depressive symptoms” “Esketamine and depression/depressive symptoms” 2.0. Article One 2.1. Research Methods The first research article by Vasiliu (2023) reviewed for this paper is based on a narrative review focusing on 14 existing research articles retrieved from different databases. 2.2. Phenomena of Interest The article under consideration aims to analyze the long-term impact of Esketamine on patients with treatment-resistant depression and compare it with the findings of short-term trials (Vasiliu, 2023).
3 2.3. Findings Relying on the data from the sample studies, the researcher has found that while Esketamine has proven evidence of effectiveness in the short term, the findings about long- term favourable or adverse impacts are mixed. Besides, the existing data does not provide adequate grounds to reach generalizable conclusions. 2.4. Safety and Ethical Considerations The researcher has properly acknowledged the contribution of all the studies and supplementary material used to obtain the information. Besides, the limitations, such as the limited data availability, have been properly acknowledged to ensure academic integrity. 3.0. Article Two 3.1. Research Methods The second research article by Herrera-Imbroda (2023) is also based on a narrative analysis of the existing literature using a mix of placebo-controlled and open-label studies. The researcher has collected the relevant studies specifically from PubMed and analysis using narrative synthesis. 3.2. Key Variables or Phenomena of Interest The article uses evidence from existing research to determine the degree to which esketamine-based nasal sprays help relieve TRD in the long term. 3.3. Findings The researcher has found that both types of studies support the drug's long-term efficacy for patients with TRD (Herrera-Imbroda). 3.4. Safety and Ethical Considerations The researcher has properly acknowledged the contributions to the research through appropriate citations and referencing conventions. Besides, the researcher acknowledges that
Your preview ends here
Eager to read complete document? Join bartleby learn and gain access to the full version
  • Access to all documents
  • Unlimited textbook solutions
  • 24/7 expert homework help