EAS Formal Lab (1)

Emily synthesized acetanilide by stirring aniline and acetic anhydride together in water at 100C. Acetanilide is a solid at room temperature, while everything else is a liquid. Emily noted that while the reaction was running, everything was dissolved and the liquid was a pale orange. Emily allowed the reaction to cool to room temperature and then cooled it in an ice bath. After the slow cooling, a solid appeared. 1. Based only on Emily's observations from this procedure, what solvent does she know will work to recrystallize the acetanilide if needed? aniline aqueous ethanol water acetic acid

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.Your colleague is helping you develop the urine test. They suggest that the urine should be adjusted to a pH above 7 before extracting with the organic solvent. Why is this necessary? Support your explanation with a full arrow-pushing mechanism for the reaction that would occur if the pH was below 7. Include all formal charges, intermediates (if applicable) and products.

A student attempted to prepare 1-chlorobutane by mixing 1-butanol with NaCl in acetone. Was the student succesful? Explain.

You are employed as a coop student at the Drug and Alcohol Testing Association of Canada (DATAC) developing analytical tests for sports doping agents. You are asked to prepare a procedure for the extraction of methylphenidate, the active compound in Ritalin, from urine samples (consider them as simple aqueous layers, you do not need to consider other components!). The goal of the procedure is to extract the methylphenidate into an organic layer which will then be evaporated, and the residue will be tested for the drug.You find that methylphenidate is highly soluble in 2-methyltetrahydrofuran, a bio-renewable solvent. Draw the structure of 2-methyltetrahydrofuran and give two reasons why it is a good solvent choice for liquid-liquid extraction.

Suppose you took your two compounds, dissolved them in tertbutyl methyl ether and then added them to a separatory funnel.  Now suppose you add in aqueous sodium bicarbonate and vigorusly shake the contents of the separatory funnel. ethanol will be dissolved in tert butyl methyl ether ether and valeric acid will be dissolved in the aqueous sodium bicarbonate layer. Draw the EXACT chemical structure that will exist in each of the layers after shaking with sodium bicarbonate.  (Is it neutral or charged?)

what would the overall reaction be for the recrystillzation of aspirin using 91% isopropanol to get pure aspirin?(drawn out) what would the mechanism be(if any)?   More information provided below:   You are removing salt, talc and other impurities to get pure aspirin. Recrystallization is a useful technique that can be used to purify solid organic compounds. Thistechnique involves the solubility of organic solids in various solvents. For recrystallization towork properly, the target compound must dissolve in a solvent when it is hot and not dissolvewhen it is cold. In this experiment you will isolate pure aspirin from aspirin tablets. Aspirin tabletscontain various salts and impurities in addition to aspirin. By using recrystallization, you will beable to remove the impurities and be left with pure aspirin.Sometimes pairs of solvents can used to produce better results. In this experiment, 91%isopropanol will be used to recrystallize aspirin. The 91% isopropanol contains 91%…

Pls solve this question correctly in 5 min i will give u like for sure Balance the chemical equation of a reaction formed by the bromination of trans-cinnamic acid if we started with 0.3088 grams of trans cinnamic acid and 1mL of bromine. The product of this reaction is 2,3 - dibromo - 3- phenylpropanoic acid

1. To pass Chem 18.1, ELIBAP must be able to determine the melting points of three ester compounds extracted and purified from three different plants. Ester 1 Ester 2 Ester 3 :0: H. MW: 182.17 g/mol MW: 152.15 g/mol MW: 164.20 g/mol Possible Melting Points: -31 °C 64-67 °C -9 °C a. Given the molar mass and molecular structures of the esters, determine their most possible melting points. b. According to her friend who took Chem 18.1 last semester, one of the ester compounds exists as a solid above room temperature (25 °C) while the rest remain in their liquid forms. Identify the ester which is present in solid form above room temperature. Draw the structure.

The purpose of this experiment is to use both extraction and crystallization techniques to separate a solid mixture of organic compounds. You will receive a packet with 1 g of a unknown (pH is basic) amide solid sample which will contain three components, one from each group: Group 1 (~50% wt):  ethyl 4-aminobenzoate, ortho-toluic acid, or benzoic acid  Group 2 (~40% wt):  fluorene, 1,4-dibromobenzene, benzil, benzoin Group 3 (~10% wt):  fluorene, 1,4-dibromobenzene, benzil, benzoin (but not the same as Group 2 compound) Create a lab procedure that will allow you to successfully isolate, purify, and identify the two major (Group 1 and Group 2) components of the unknown amide sample.  reagents that can be used are 1M HCl, 6M HCl, 1M NaOH, 6M NaOH, diethyl ether, and methylene chloride

Vanillin, NaI/NaOCL, ethanol/H2O, bleach are reacted in an electrophilic aromatic substitution leading to the product 5-Iodovanillin. Please help me by drawing out a separation scheme. I need to see where each compound ends up leading up to the final product as it is being made into a solid precipitate.

To determine the purity of a synthetic preparation of methylethyl ketone, C4H8O, it was reacted with hydroxylamine hydrochloride, liberating HCl (reaction: NH2OH.HCl + C4H8O -> C4H9NO + H20 + HCl). In a typical analysis a 3.00-mL sample was diluted to 50.00 mL and treated with an excess of hydroxylamine hydrochloride. The liberated HCl was titrated with 1.2149 M NaOH, requiring 35 mL to reach the end point. A. Write the acid base reaction involved in the titration. B. Report the percent purity of the sample given that the density of methylethyl ketone is 0.805 g/mL.

OH 0140769 filler EXPERIMENT 11 RADICAL COUPLING REACTION (Preparation of 1, 1-bis-2-naphthol) FeCl3 - Drop of H₂O - Grinding - rt OH 1.13909 1, 11199 1.13579 Chemicals Required: 2.88069 2.8843 2-Naphthol - 2.88 g Iron(III) chloride - 1.10 g Water - 2 drops -sumins 2.88 242 Toluene (for recrystallization) 640 41725 P Procedure: 2.8 0.1082 Grind a mixture of 2-naphthol (2.88 g) and iron(III) chloride (1.10 g) with 2 drops of water in an agate (or porcelain) mortar pestle for about 20 minutes. Allow the mixture to stand for 1 hr 10 mins with a little grinding now and then. Transfer the mixture with water (40 ml) into a 100 ml beaker and boiled for 10-15 minutes. Cool the mixture and filter the product, wash with boiling water (10 ml), dry and recrystallize from toluene. Report the yield and melting point of the product. Remember to hand in your product. Data Treatment and Analysis 1. Calculate the % yield for the product and show your working. Determine the % error if possible. 2.…

Khaira performed the synthesis of ester X. Liquid-liquid extraction is needed to extract compound X fromthe aqueous reaction mixture. Given the solubility of ester X in the following solvents.  Solvent  Solubility of Compound X (g/mL solvent) at 25°C water 0.278 ethanol  1.027 acetone  1.309 dichloromethane  0.891 diethyl ether  0.759 a. Which solvent must she use to extract compound X? b. Calculate the KD. c. She transferred all of the aqueous reaction mixture in a separatory funnel, and she added 100 mL of theBEST solvent (from question a). If the total volume of the reaction mixture is 100 mL, calculate the g ofcompound X that will be extracted. (Based on literature; 5.0 g of the product will be synthesized from theamount of starting material she used.) d. Her partner, Jane, repeated the same experiment but this time, she performed the liquid-liquid extraction twiceusing 50 mL of the BEST solvent (from question a). Calculate the g of compound X that will be…

10. Fractional Distillation: This lab was viewed via a video and described in detail in lab class. You are distilling apart hexane (bp = 68) and toluene (bp 110). Your boiling point for the first fraction is 48°C. Why is the boiling point so low (most likely reason)? !! azeotrope with water non-resonance of hexane O resonance of toluene student error O seriously impaired thermometer

A mixture of the two compounds shown below is dissolved in ether. Using the information given in the experiment, select all the correct statements regarding the extraction and isolation of the two compounds. محمد age X Y A. X can be extracted from the organic layer using hydrochloric acid. OB. Y can precipitate if hydrochloric acid is added to the salt of Y in the aqueous layer. OC. Y can be extracted from the organic layer using hydrochloric acid. D. X can precipitate if hydrochloric acid is added to the salt of X in the aqueous layer

10) Write an equation for the reaction of n-propyl magnesium chloride and butanal (Not 3- methylbutanal). Why was it important to have dry equipment that was heated in oven and a drying tube placed on top of the condenser for the above-mentioned reaction? Explain?

Synthesis of p-Bromoaniline The student observes a melting point of 110-113 C for the acetanilide. The literature melting point is 114 C. Which conclusion can he draw from these observations? (Check all that apply)  a) The compound has 98 % purity.    b) The sample is still wet.    c) The solid is impure.    d) The isolated compound in the target compound.

Aldehydes can be determined indirectly by atomic absorption. The aldehyde is oxidized with the Ag+ ion producing 2 moles of Ag for every mole of the aldehyde. Silver dissolves and is determined by atomic absorption. When examining a liquor, 50 mL were subjected to the treatment, the metallic silver was separated and dissolved, making the resulting solution 20 mL for its reading. A 10 ppm Ag solution was examined under the same conditions; The readings obtained were: 0.423 and 0.242 for the standard and the sample respectively. Assuming full adherence to Beer's Law, calculate the mg of acetaldehyde in 100 mL of liquor.

Imagine that phenol (“hydroxybenzene”) and nitrobenzene are reacted (in separate beakers) with a hot solution containing both concentrated sulfuric acid and concentrated nitric acid. A) In analyzing the products, you discover that the substitution pattern resulting from the reaction with phenol differs from the reaction with nitrobenzene. Explain this difference in substitution patterns using one or more judiciously selected reaction mechanisms or portions of mechanisms.

b. When added to an immiscible mixture of dichloromethane and water, which layer would you expect the following compounds to primarily be found in? Explain. i. limonene CH3 CH3 CHM 2070 Lab Fall 2020 ii. acetic acid HOCH3 i. benzaldehyde

Data: Density of p-phenetidine is 1.065g/mol Williamson Ether Synthesis: Mass of filter paper:   0.680 g Mass of filter paper and product:  1.482 g Melting Point:  134-136oC Amide Synthesis: Mass of filter paper:   0.686 g Mass of filter paper and product: 1.589 g Melting Point:  135-137oC Mixed Melting Point (product of amide synthesis mixed with Williamson Ether synthesis product): 134-136oC (a)Calculate theoretical yield of both williamson ether synthesis of phenacetine and amide synthesis of phenacetin. (b) calculate the percent yield of phenacetin obtained via williamson ether synthesis. (c) Calculate the percent yeild of phenacetin obtained via the amide synthesis.

A student was performing an acid-base extraction of a mixture of three compounds. The three compounds in the mixture are shown below. The mixture was extracted wilth 6 M HCI three times. The combined extractions were put into a flask marked A, which was treated with 1 M NAOH till it turned basic. This was then evaporated to obtain a crystal, which we label A. The remaining mixture was extracted with 6 M NaOH three times. The combined extractions were put into a flask marked A, which was treated with 1 M HCI till it turned acidic. This was then evaporaled to obtain a crystal, which we label B. The remaining mixture was evaporated to obtain a crystal, which we label C. The identity of A is Select] The identity of B is (Select) The identity of Cis Select] OH NH2 3

Three sample, X (neutral), Y (basic), and Z (acidic), were mixed and dissolved together in dichloromethane. Propose a method to separate all given sample individually using the combination of liquid-liquid extraction, crystallization, distillation, and sublimation technique.

Pcdotte Use a flow chart to show how you could separate a mixture of the following compounds using an extraction. Be sure to include all steps to get pure materials. НО.

Which method can be used to prepare CH3CH2CH2CH2NH2? NH3 (large excess) (a) CH3CH2CH2CH2B. (1) NaCN (2) LİİAIH, (3) H20 (b) CH3CH2CH2B NH3, mild acid (c) CH3CH2CH2CHO NABH3CN or NABH4 (d) All three methods would work. Answer (a)

Retention time, min Name of Compound 10.767 Benzaldehyde 15.790 Azulene 16.002 1-Piperazinecarboxaldehyde 17.935 Phthalan 20.731 2-methoxy-1,3,4-trimethybenzene 24.028 Methylesterpentanoic acid 26.993 Tetradecamethylcycloheptasiloxane 31.753 Hexadecamethyl Cyclooctasiloxane If GC is combined with MS, what data you will add as the 3rd column in Table 1 above. Fill in that data for each of the select identified phytocomponents.

How to set-up a separatory funnel? Please narrate the process in 5 sentences.

REACTION Acidic conditions REACTION Basic conditions In a round-bottom flask of appropriate size attached over a stirring plate, stir 4-methoxyacetophenone (6.00 mmol) and acetic acid ([ketone] = 0.90 M) until homogeneous. Add bleach (6% m/v NaOCI, 1.60 eq.) slowly, over a few minutes. Allow the mixture to stir at room temperature for 20 minutes, then monitor the reaction by TLC. If starting material can still be found, add a slight excess of bleach (0.10 eq.), stir an additional 10 minutes and check again by TLC. In a round-bottom flask of appropriate size, add sequentially 4-methoxyace- tophenone (3.50 mmol), bleach (6% m/v NaOCI; 6.00 eq) and 3M NAOH (1.00 eq.). Asemble a reflux apparatus, and boil the resulting mixture for approximately 20 minutes. Analyze the reaction by TLC: if the reaction is still ongoing, reflux an additonal 5 minutes before repeating this TLC step. Once over, add ~2 mL of acetone to the mixture through the condenser. Allow the solution to gently boil for…

In the synthesis of Sudan-1, the following precursors were used: Aniline – 0.2 mL β-naphthol – 0.35 g   Experimental data Weight of vial, g 13.1085 Weight of vial + recrystallized product, g 13.4714 Experimental melting point, °C 129-132 Given this data: What is the theoretical yield? What is the percent yield? What is the purity of the dye based on experimental melting point (theoretical is 131-133 °C) Please show solutions and equations

Following is a retrosynthetic analysis for the anthelmintic (against worms) diethylcarbamazine. N. `NET2 N. OEt Me Me Diethylcarbamazine (A) (2) OH MENH, CI OEt Me OH Me Methylamine Ethylene (C) (В) Ethyl oxide chloroformate Diethylcarbamazine is used chiefly against nematodes, small cylindrical or slender threadlike worms such as the common roundworm, which are parasitic in animals and plants. Given this retrosynthetic analysis, propose a synthesis of diethylcarbamazine from the three named starting materials.

If 80% of a desired compound is extracted into the organic phase in each step (leaving 20% in the aqueous layer), how many extractions are necessary to ensure that at least 99% of the compound has been recovered in the organic phase?      1 extraction     2 extractions     3 extractions     4 extractions

Interpretate the results and identify the type of reaction involved.

The nitration of the 2-amine toluene is able to occurs with only nitric acid. Interestingly it occurs to the meta position in relation to the amino group. Amines are stronger activators compared to the methyl groups. Explain in your own words a feasible reason to explain why the reaction takes place at this position and not ortho/para in relation to the amine. CH HN. HN. 65% HNO, Ethanol NO MeSO,H Imatinib einhainnente nale PatnteUI