1. The act or result of amplifying, enlarging, or extending. 2a. An addition to or expansion of a statement or idea. b. A statement with such an addition. 3.Physicsa. The process of increasing the magnitude of a variable quantity, especially the magnitude of voltage, power, or current, without altering any other quality. b. The result of such a process. 4.Electronics See gain1 (sense 4). 5.Genetics The process by which extra copies of a gene or a DNA sequence are formed.