Answered: You want to find a drug which inhibits…

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter9: Cell Communication

Section: Chapter Questions

Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...

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Question

You want to find a drug which inhibits this calcium response pathway in normal cells where it is activated by a signal molecule (red dot). You decide to do mass screening to find that drug. You obtain a large collection of chemical compounds to screen. You make sure that they do not kill the cells and you test them in the following way: you treat the cells with the compounds and then stimulate the cells with the signal molecule (red dot) and analyze the response. Only one compound had an effect you call it drug#1. When the cells are treated with drug#1, and then stimulated with the signal molecule, you find that: 1) cytosolic calcium concentration is low, 2) DAG is not found in membranes, and 3) G-proteins binds GTP normally in drug-treated cells. Give a possible mechanism of action of this drug.

STUDENT NAME:
signaling
otein coupled receptor (GPCR) signaling pathway:
PI 4,5-bisphosphate
(PI(4,5)P2]
signal molecule
activated GPCR
activated
phospholipase C-B
diacylglycerol
al
rge
n.
GTP
activated
protein
inositol
1,4,5-trisphosphate
(IP)
activated G.
kinase C
Ca 2+
open IP,-gated
protein
Ca-release
channel
lumen of
endoplasmic
reticulum
3) G-proteins binds GTP normally in drug-treated cells.
rug.

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