Thomas rides in an elevator with a young child suffering from the common cold. Like most young children, the sick girl fails to cover her mouth when she sneezes thus releasing cold viruses (Rhinoviruses) into the air of the elevator. Thomas has the misfortune of inhaling one of those viruses. These questions follow step-wise as Thomas’ immune system attempts to prevent the infection. 1)Identify three physical barriers in Thomas' nasal cavity that attempt to prevent infection by the virus. The dastardly virus sneaks past those barriers and enters a nasal mucosa cell. The virus hijacks the transcription machinery of the cell to produce more virus particles. These particles then infect neighboring cells. 2) [_______] is a proteinaceous component of the innate immune system that interferes with the infection of neighboring cells with virus particles. 3) Some of the infected cells are phagocytosed. Phagocytes present antigens from the infected cell on the cell surface bound to a glycoprotein, found only on professional antigen presenting cells (APCs). This glycoprotein is called [_______]?
Thomas rides in an elevator with a young child suffering from the common cold. Like most young children, the sick girl fails to cover her mouth when she sneezes thus releasing cold viruses (Rhinoviruses) into the air of the elevator. Thomas has the misfortune of inhaling one of those viruses. These questions follow step-wise as Thomas’ immune system attempts to prevent the infection.
1)Identify three physical barriers in Thomas' nasal cavity that attempt to prevent infection by the virus.
The dastardly virus sneaks past those barriers and enters a nasal mucosa cell. The virus hijacks the transcription machinery of the cell to produce more virus particles. These particles then infect neighboring cells.
2) [_______] is a proteinaceous component of the innate immune system that interferes with the infection of neighboring cells with virus particles.
3) Some of the infected cells are phagocytosed. Phagocytes present antigens from the infected cell on the cell surface bound to a glycoprotein, found only on professional antigen presenting cells (APCs). This glycoprotein is called [_______]?
4) Which of the cell types present antigens?
5) Presentation of the viral antigen bound to MHC II by APCs activates cells with CD [___] markers. These cells are called [____] cells.
6) Another type of adaptive immune cell can recognize viral infected cells and attack them directly with perforins and granzymes. It recognized the infected cell due to the presence of viral proteins on the cell surface of the infected mucosa cells bound to [________].
7) This type of cell is called a [_______].
8) Create a flow chart showing the activity of the various components of the immune system, sequentially, that are activated by a viral infection.
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