The results of QTL mapping studies for human diseases tend to show that disease-causing alleles are either rare or have very small effects on risk. Knowing that this is true, discuss the evolutionary forces that are most likely to be responsible for this state of affairs. Does this observation suggest something about the evolutionary forces that maintain disease risk in human populations?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter10: From Proteins To Phenotypes
Section: Chapter Questions
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The results of QTL mapping studies for human diseases tend to show that disease-causing alleles are either rare or have very small effects on risk. Knowing that this is true, discuss the evolutionary forces that are most likely to be responsible for this state of affairs. Does this observation suggest something about the evolutionary forces that maintain disease risk in human populations?

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