The most common CF mutation is AF508; it accounts for approximate 70% of all mutant CFTR alleles worldwide. For a couple of northern European origin, what is their risk for having an affected child if each tests negative for AF508? If one tests positive and the other tests negative for AF508?
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- O. 2 Hemophilia A is an X-linked trait where blood clotting is affected due to a mutation in a clotting factor protein. Georgio has hemophilia and attends a support group where he meets Gbenga, who does not have the disease, but whose father has hemophilia. Her mother is not affected. A) If they marry, what percentage % of all their children will have hemophilia? % B) Georgio meets another woman, Maria, at the hemophilia support group. Maria also lacks the trait, but her mother has hemophilia while her father is unaffected. # 3 Would a Georgio-Maria mating provide a larger chance of having afflicted children compared to a Georgio-Gbenga mating? C) Show how you came up with your answer to B. Edit View Insert Format Tools Table 12pt ✓ 80 F3 V Paragraph ✓ $ 4 Yes or No 000 000 F4 DO LO % 5 BIUAV T² | F5 ^ MacBook Air 6 2 F6 V & 7 F7 * 8 DII F8 ( 9 DD F9 1 0 S FJacob and Patau Syndromes List the similarities and differences between these two syndromes. Which of the syndromes is more severe?Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF, nor does Tony. Tony is expecting a child with Tina. Tina does not have CF, but otherwise her family history is unknown. A) What is the probability that Tony is heterozygous for the CF gene? B) If the frequency of heterozygotes in the general population is 1/50, what is the probability that Tony and Tina's child will have CF?
- What is the frequency of sickle cell disease (anemia)? https://ghr.nlm.nih.gov/condition/sickle-cell-disease#inheritance https://www.cdc.gov/ncbddd/sicklecell/traits.htmlCystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?Mr and Mrs Connelly are planning to start a family. However, Mr Connelly is concerned that, as his brother was diagnosed with cystic fibrosis (CF), he may be a CF carrier. Their GP explains how Mr Connelly may carry the faulty CFTR gene using a Punnett square. create two separate Punnett squares and explain in detail the possible outcomes for the children of two different sets of parents as follows: Set A parents are both carriers of Huntingdon’s Disease, and in Set B only one parent is a carrier of Huntingdon’s Disease. Explain the results in detail of each Punnett Square
- Sickle cell anemia is a genetically inherited autosomal recessive trait in which results in a condition that there are not enough healthy red blood cells to carry oxygen throughout the body due to the production of red blood cells that are sickle shaped. The frequency of the sickle cell condition is as high as 10% in Central Africa compared to 0.5% in the United States. Calculate the frequency of the normal and carries of the sickle cell condition.Why Recessive CF disease alleles either produce no CFTR or produce nonfunctional or less functional versions of the protein?A) what are the genotypes for EB27 and EB67? B) what is the relationship between the three alleles (B,br, y)? Show evidence using the pedigree
- In Huntington’s disease, the wild-type allele, h, is recessive to the disease allele, H. The persistence of an autosomal dominant allele that is fatal in 100% of cases is best explained by which of the following? A) The dominant allele only has moderate negative effects during adolescence and young adulthood. B) The wild-type h allele continues to spontaneously mutate into the dominant H allele. C) The persistence of any given allele in nature is determined almost wholly by chance. D) The disease has no effects until the individual has reached an age far past the normal age for reproduction.APOE gene has been found to be a major contributor to sporadic Alzheimer's disease (AD), by acting as an age-of-onset modifier for the common relatively late-onset forms of the disease. Among four alleles causing early onset of AD, the epsilon4 allele (APOE4) disrupts this function. If you generate transgenic monkeys in which the normal allele of APOE gene is knocked out, what phenotype will you expect for those knockout monkeys? A. The APE mRNA expression will be completely suppressed. B. They slow down the development of AD. C. They develop AD early. D. They don't show any AD symptom.what are the other system of blood typing besides ABO group? Give at least 3 and what are the modes of inheritance (Autosomal dominant, recessive or sex linked dominant, recessive or multifactorial or mitochondrial) of these blood groups?