the metabolite is an active drug what will happen to the efficacy of the drug following saturable hepatic metabolism given at a high dose? Is it desirable or not?
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If the metabolite is an active drug what will happen to the efficacy of the drug following saturable hepatic
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- What are the advantages of intravenous infusion of glucose than other injection like subcutaneous and intramuscular?A client with Type 1 diabetes mellitus is admitted to the hospital in a semi-conscious state with fever, nausea, and vomiting. The urine sample was positive for ketone bodies. Which of the following statements regarding the client is correct? Question 80 options: a) Glucagon should be administered to stimulate glycogenolysis and gluconeogenesis in the liver b) An injection of insulin will decrease ketone-body production c) The client should be started on a glucose infusion to help them regain consciousness d) The client's blood glucose level is well below 4.4 mmol/LAn unresponsive client who has diabetes is brought to the emergency department with rapid, deep respirations. Additional findings include: blood glucose 24.9 mmol/L, arterial pH 7.2 and urinalysis showing presence of ketones and glucose. Which of the following statements best describes the underlying cause of this patient’s presentation? Question 64 options: a) Relative insulin deficiency, causing hyperglycemia, oxidative stress, renal dysfunction and acidosis b) Nocturnal elevation of growth hormone resulting in hyperglycemia in the morning c) Absolute insulin deficiency, increased counter-regulatory hormone, lipolysis and free fatty acid release d) Hypoglycemia causes release of glucagon, resulting in glycogenolysis and hyperglycemia
- In a diagnostic examination of a patient’s thyroid, the patient, who weights 70 kg, is given a capsule containing 10 micro Ci 131I. Thirty percent of the radioiodine is rapidly taken up by the thyroid, whose weight is estimated as 30 g. Given that 1) the biological half-life of iodine in the thyroid is 120 days, 2) the radiological half-life 131I is 8 days, and 3) the average absorbed energy in the thyroid is 0.21 MeV per disintegration, calculate the a) effective half-life of the radioiodine in the thyroid, in days, b) effective turnover rate of the radioiodine in the thyroid, in percent day-1, c) mean residence time of the radioiodine in the thyroid, in days, d) time for 90% of the radioiodine to be cleared from the thyroid, and e) committed dose to the thyroid, in cGyABC is an oral medicine and is a co-formulation containing Drug X and Drug Z. When administered alone, Drug X which is the active ingredient, exhibits poor bioavailability. Drug X is known to be metabolised by hepatic CYP enzymes. Studies have shown that addition of Drug Z results in higher blood levels of Drug X. 1) How this might be possible ? 2) Predict possible changes to the pharmacokinetic parameters of Drug X when co-administered with Drug Z ? 3) Clinical outcomes brought about by using this co-formulation ABC ?What is the pharmacodynamics that elevates the INR in a patient taking Warfarin and Motrin together?
- Why is it that intravenous infusion of glucose is given to a patient?How soon following acute abdominal pain due to pancreatitis is the serum amylase level expected to rise? 1) 1-2 hours 2) 12-24 hours 3) 6-12 hours 4) 3-6 hours no references, just homeworkIf a diabetic patient has a high level of sodium and urea but a low level of potassium. Which of thefollowing solutions will you give them: a) A saline solution (high in sodium and potassium) with low glucoseb) A solution with no salts just waterc) A solution with low sodium and urea but high in potassiumd) Nothing, the patient’s insurance was not accepted.
- A publication about the Nurses’ Health Study found a correlation between glycemic load and mortality. What is meant by glycemic load? Question 52 options: a) Glycemic load is a measure of blood glucose response to different carbohydrates compared with glucose b) Glycemic load is the weight of the food plus a correction for the amount of fibre the food contains c) Glycemic load describes how many grams of glucose food releases into the bloodstream d) Glycemic load is based on glycemic index of a food but takes into account the amount of available carbohydrate in a serving of that foodA client with T2DM is admitted to the medical unit with pneumonia. The client’s oral antidiabetic medication has been discontinued and the patient is now receiving insulin for glucose control. Which of the following statements best explains the rationale for this change in medication? Question 73 options: a) Insulin administration will help prevent hypoglycemia during the illness b) Acute illnesses like pneumonia will cause increased insulin resistance c) Infection has compromised beta cell function so the client will need insulin from now on d) Stress-related conditions such as infections induce a hypermetabolic stateWhy is it important to be knowledgeable about the benefits of taking vitamins in our body and the dosage recommended to intake? How precursor related to the vitamins(long explanation pls) Why is it significant to determine the importance of dietary supplements, including their active agent, and to know if it is necessary or not? (long explanation pls) kindly answer :)) thank you so much!
