Study the given alleles. Write the correct phenotype for each genotype. X– normal Genotype XC – Color-blind Phenotype XX XY ww wm XXC www XY Study the given alleles. Write the correct genotype for each phenotype. X – normal Genotype хн- Hemоphiliac Phenotype Hemophiliac female Hemophiliac male Normal female carrier of the gene Normal male Normal female
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- The genotype XXY corresponds to Klinefelter syndrome Turner syndrome Triplo-X Jacob syndrome1. Study the given alleles. Write the correct phenotype for each genotype. X – normal Gen otype xC - Color-blind Phenotype XX XY XXC xCY 2. Study the given alleles. Write the correct genotype for each phenotype. xH - Hemophiliac Phenotype X- normal Gen otype Hemophiliac female Hemophiliac male Normal female carrier of the gene Normal male Normal female 28 3. Determine the genotype and phenotype of the offspring. A color-blind mother (XCx) married a normal sighted (XY) father. Genotype: Phenotype: Genotype: Phenotype: Genotype: Genotype: Phenotype: Phenotype: a. There are b. There are c. There are d. There are % normal sons. % normal daughters. % color-blind sons. % color-blind daughters. % normal female, carrier of the disorder. or or or or e. There are orD. Sex-linked In humans, hemophilia is a sex-linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won't ever be carriers). 1. Show the cross of a man who has hemophilia with a normal woman. What is the probability that their children will have the disease? H H = female, normal H h X X = female, carrier h xxn XHY X" Y 2. A woman who is a carrier marries a hemophiliac man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? 3. A woman who has hemophilia marries a normal man. How many of their children will have hemophilia, and what is their sex? = female, hemophiliac = male, normal = male, hemophiliac
- 1. In humans, hemophilia is a sex linked trait. Females can be normal, carriers, or have the disease. Males will have the disease or not (but they won't be ever carriers) XH XH = female, normal XH Xh = female, carrier Xh Xh = female, hemophilic XH Y = male, normal Xh Y = male, hemophilic a) Show the cross of a man who has hemophilia with a woman who is a carrier. b) What is the probability that their children have the diseaseA. For the following genotypes state the ABO blood phenotype. JAJA |B|O_ 101⁰_ |A|B_ B. Using genetic diagrams, show how it is possible for a couple with a type A mother and a type B father can have a child with type O blood. C. Using genetic diagrams show how a type AB person with a type O partner have offspring that share neither of their phenotypes.b. The following diagram shows a family tree of individuals with haemophilia. B i. Based on an X-linked recessive pattern of inheritance, work out the likely genotypes of the individuals indicated by the letters. Individual A Individual B Individual C GENOTYPE ii. If individual C has children with a normal male, what are the chances that they will have haemophilia? Explain your answer fully. iii. If individual C has children with a normal male, what are the chances that their daughters will be carriers of the condition? Explain your answer fully.
- Finally, draw out a Punnett square to help you consider the cross between these possible gametes. Sex-Linked1 := Homework • Unanswered What are the possible genotypes of the offspring shown in your Punnett square? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. XBxb and xbY a b XBXB and xbY Neither of these answers is correct Unanswered • 1 attempt left Submit Sex-Linked2 Homework • Unanswered What are the possible phenotypes of the offspring? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a Females with normal color vision and males who are colorblind Females who are colorblind and males who have normal color visionPlease select all of the following that are x- linked disorders. O Cystic Fibrosis red-green color blindness O Hemophilia Duchenne Muscular Dystrophy O Down SyndromeII. Write TRUE if the statement is correct and FALSE if otherwise. -7. A temale parent possessing an X-linked dominant mutation is considered a carrier and will not manifest clinical symptoms of the disorder. _8. Y-linked traits are passed from the father to son, without the occurrence of genetic recombination. 9. Somatic mosaicism results to abnormalities based on the amount and distribution of normal cells while gonadal mosaicism affects the germline tissues leading to a new dominant mutation. 10. A test cross is done to determine which allele is dominant and which is recessive.
- d Dd 501. s0% 5. Another type of blood disorder is hemophilia, which is an X linked disorder caused by a recessive allele. Like VWD, this disorder interferes with the protein that is involved with blood clotting. Known as "bleeder's disease" because any minor injury can become life threatening. This disorder is considered more severe than VWD. In both cases there are versions of the disorder that can be less and more severe depending on which protein or clotting factor is affected. Normal XHY Normal X"Xh Carrier XhY Hemophilia Bourthelesm X"Xh Hemophilia If a woman is a carrier, what percentage of her SONS will have the disorder? How many (%) of their sons will have hemophilia? How many (%) of their sons will be normal? How many (%) of their daughters will be normal? 6. A man who has hemophilia marries a normal woman (not a carrier)... How many (%) of their sons will have hemophilia? How many (%) of their daughters will be carriers 7. A woman who is a carrier marries a man with…AaBbCcDc AaBbCcD Ac Heading 1 Heading 2 Title Subtitle Subtle Em.. Emphasis Intense E... Strong Quote Int Paragraph Styles 4 Genetic Inheritance Patterns Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Eric's form of RP is Usher's Syndrome, which is an autosomal recessive inheritance (i.e., you must get a copy of the defective carried on one of the chromosomes that determines sex. Usher's Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition. His brother, Dirk, does not have any symptoms of RP. gene from your Mom and one from your Dad). Autosomal means it is not Question below short answer approach image you are the genetics counselor, should Eric have children? Imagine he has a daughter (he has two, but both are adopted). What advice would you give Eric if his wife was a carrier from a genetics counseling viewpoint? Describe all the possibilities,…What percentage of all children will be carriers? What is the sex of the carriers? 2. A heterozygous woman carrying the recessive gene for hemophilia marries a man who is not a hemophiliac. Assume the dominant gene is X" and the recessive gene is X". The woman's genotype is X"X", and her husband's genotype is X"Y. What is the potential percentage and sex of their offspring who will be hemophiliacs? % males; % females 100 What percentage can be expected to lack the allele for hemophilia? What is the anticipated sex and percentage of individuals who will be carriers for hemophilia? 2014 sex %,