Latrotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA
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Latrotoxin
identify the species which releases the toxin (if it is man-made then this will be all that is required for this part)
- identify the step disrupted in the neuromuscular junction pathway
- Provide any consequences of this disruption.
- Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic?
- Provide your source in APA format for each. If this is missing no credit will be awarded.
Step by step
Solved in 2 steps
- Lophotoxin identify the species which releases the toxin (if it is man-made then this will be all that is required for this part) identify the step disrupted in the neuromuscular junction pathway Provide any consequences of this disruption. Does the toxin have any applications in biomedicine as a painkiller, disease treatment or analgesic? Provide your source in APA format for each. If this is missing no credit will be awarded.Read this article and answer the following question There are 3 different Metformin ER products available: Glucophage XR Glumetza ER Fortamet ER All 3 formulations are available generically but they are not interchangeable as they all use different release mechanisms. Glucophage XR uses a dual hydrophilic polymer system. The drug is slowly released by diffusing through a gel matrix, also known as GelShield diffusion system. Once the tablet is swallowed, the outer layer of the tablet forms a gel layer and the metformin contained within is slowly released. Due to this release mechanism, Glucophage XR can not be cut or split. Glumetza ER uses a mechanism known as gastro-retentive technology (also known as 'Modified Release'). The tablets are designed to remain in the stomach and deliver metformin to the upper GI tract over an extended period of time. Like Glucophage XR, Glumetza ER can not be cut or split. Fortamet ER uses single-composition osmotic technology (SCOT). After…For each of the following examples, indicate whether the drug is acting on physical process, chemical process or enzymatic system (your answer should be only; Physical, Chemical or Enzymatic). Group of answer choices 1. A drug is used as an antidote in lead poisoning and acts by binding to lead particles in body (chelation therapy). 2. A drug acts to reduce flatulence and acts by reducing the surface tension of intestinal gas bubbles in the GI tract (e.g. Simethicone). 3. A drug competes with alpha-glucosidase in intestine to reduce glucose conversion from disaccharides (e.g. Acarbose).
- A patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…A 70-year-old woman visited her GP complaining of a sore throat, a fever (38.5°C), and recent loss of appetite and tiredness. She reported dark urine and her stools were unusually pale. There was no history of foreign travel and she stated that she abstained from alcohol. No other medication reported. Test Unit Result Reference range Bilirubin µmol/L 68 ≤17 Aspartate aminotransferase (AST) U/L 302 ≤30 Alanine aminotransferase (ALT) U/L 395 ≤37 Alkaline phosphatase (ALP) U/L 295 ≤150 Albumin g/L 39 35-45 Gamma-glutamyltranspeptidase U/L 298 ≤55 Prothrombin time s 12 11-13 Haematology Lymphocytosis noted on blood film Further tests showed positivity for IgM anti-EBVHello good day, I am having a problem answering this question and I need your help on this. Hoping for a response and thank you In each chosen disease, pls. supply the information below: So I've chosen "Phenylketonuria (PKU)", so I need a short description, its pathophysiology, laboratory diagnosis, and Treatment and Prevention of my chosen disease. a. Short Description b. Pathophysiology c. Laboratory Diagnosis d. Treatment and Prevention
- This is a walk-through of Minimum Inhibitory Concentration, MIC: This tray has 8 rows, 4 for Staphylococcus aureus (SA) and 4 for Methicillin-Resistant S. aureus (MRSA). Each row has 12 compartments, or wells. The wells have different concentrations (ug/ml) of the antibiotic Oxacillin in them. From Left to Right, the concentration of Oxacillin is going down acillin concentration, pg/ml 64 32 16 8 4 2 1 0.5 0.25 0.13 0.06 0 SA dn The same amount of S. aureus broth culture is added to each well and the tray is incubated. A color change shows that S. aureus grew in a given well. MRSA What is the lowest concentration at which SA is inhibited (does not grow)? 64mg/ml What is the lowest concentration at which MRSA is inhibited? What is the MIC for Oxacillin vs SA? What is the MIC for Oxacillin vs MRSA? - Notes Comments 33°FA client has been ordered methyl Pprednisulune 30omg luPB In 30mL D5W Over 15 min.stat fur an asthma att-acis. in Stous,you have methylpredrisolune 500mg vials . The reconstitutiun Instructions are: Add 7.8mL G Sterile uater and shale genly Each reconstituted uial contains 8mL. a) Houw nmuch medieation will you draw up? 6) what is the Infusion rate in mt/ hr ?The dose of mitomycin injection is 20 mg/m2/day. Determine the daily dose for a patient whoweighs 144 lb and measures 68 inches in height.
- Doris has reconstituted a bottle of Cefprozil® Oral Suspension to fill a patient's prescription. The prescription calls for 400 mg CefprozilⓇq12h for 7 days. Doris needs to know if the amount of reconstituted medication in the bottle will be enough to last the patient for 7 days. Calculate the total amount of medication in the bottle after this medication has been reconstituted: TEVA Seferle, PA 18960 PHARMACEUTICALS USA SHAKE WELL BEFORE USING KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN 5 mL (approx. one teaspoonful) of suspension. Phenylketonurics: This product contains 10.1 mg of phenylalanine per Store constituted suspension in refrigerator. Discard after 14 days Ruv. A 7/2005 L52974 NDC 0093-1075-78 CEFPROZIL for Oral Suspension USP 125 mg/5 mL* Each 5 mL, when constituted according to directions, contains 125 mg anhydrous cetprozil, Ronly 75 mL (when mixed) TEVA To the Pharmacist: Prepare suspension at time of dispensing. Add to the bottle a total of 59 ml water.…The plate below is a test of 7 different antibiotics against Enterobacter aerogenes. The center disc is Ciprofloxacin 15 micrograms) and the 24 hour extent of the Zone of Inhibition is the farther diameter. The one below it and slightly to the right is Chloramphenicol (30 micrograms) [see red arrow}. Give me the extent of the Zone of Inhibition in mm (yes, use a ruler and measure it at the size it comes up on your computer screen), then use the Standard Table and determine R, I, S for each. Antibiotic Zone of Inhibition (mm) R, I or S Drug target Ciprofloxacin Chloramphenicol Which of the 2 drugs is more selective and why?In the design of H2 antagonists, the polar guanidine group of compound A was proposed to interact with the antagonist binding region by two hydrogen bonds. This compelled researchers to derivatize compound B from compound A. HN EN Chain Extension Rigidification ZI compound A What drug design strategy has been used here? Simplification H₂N NH Substituent variation HN NH₂ HN NH N compound B