In general, which of the following statements about nucleophilic reactions are true ? Select all that apply. | Steric hindrance in the substrate is irrelevant in SN1 reactions. E2 reactions rely on least substituted substrates. 1° are best while 3° are worst. Hindered strong bases are expected to result in Hoffman products whenever feasible.

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter20: Acidity And Pka Of Phenols
Section: Chapter Questions
Problem 11E
icon
Related questions
Question

the above answers are incorrect please fix it

In general, which of the following statements about nucleophilic reactions are true ?
Select all that apply.
Steric hindrance in the substrate is irrelevant in SN1 reactions.
E2 reactions rely on least substituted substrates. 1° are best while 3° are worst.
Hindered strong bases are expected to result in Hoffman products whenever
feasible.
Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are
preventing SN1/E1 reactions.
Polar protic, neutral or acidic solvents/environments like alcohols, water, or
acidic solutions inhibit SN2 mechanism.
Transcribed Image Text:In general, which of the following statements about nucleophilic reactions are true ? Select all that apply. Steric hindrance in the substrate is irrelevant in SN1 reactions. E2 reactions rely on least substituted substrates. 1° are best while 3° are worst. Hindered strong bases are expected to result in Hoffman products whenever feasible. Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are preventing SN1/E1 reactions. Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions inhibit SN2 mechanism.
Hindered strong bases are expected to result in Hoffman products whenever
feasible.
Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are
preventing SN1/E1 reactions.
Polar protic, neutral or acidic solvents/environments like alcohols, water, or
acidic solutions inhibit SN2 mechanism.
E2 reactions rely on antiperiplanar conformation with respect to leaving group
and the hydrogen that are being eliminated.
E1 reactions do not depend on the performance of the leaving group.
Transcribed Image Text:Hindered strong bases are expected to result in Hoffman products whenever feasible. Polar aprotic solvents like HMPA, DMF, DMSO, acetonitrile, or acetone are preventing SN1/E1 reactions. Polar protic, neutral or acidic solvents/environments like alcohols, water, or acidic solutions inhibit SN2 mechanism. E2 reactions rely on antiperiplanar conformation with respect to leaving group and the hydrogen that are being eliminated. E1 reactions do not depend on the performance of the leaving group.
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Protection of Groups in Organic Synthesis
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Organic Chemistry: A Guided Inquiry
Organic Chemistry: A Guided Inquiry
Chemistry
ISBN:
9780618974122
Author:
Andrei Straumanis
Publisher:
Cengage Learning
EBK A SMALL SCALE APPROACH TO ORGANIC L
EBK A SMALL SCALE APPROACH TO ORGANIC L
Chemistry
ISBN:
9781305446021
Author:
Lampman
Publisher:
CENGAGE LEARNING - CONSIGNMENT
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning