Identifying Neurotransmitters3) Produces response in postsynaptic cell- Qualifying condition: Molecules evoking same response as neurotransmittersPresynapticterminalPostsynaptic.dendriteDrug-containingmicropipette(753)Apply drugby passingelectricalcurrentStimulateaxonRecord VDrug applicationthrough themicro-pipetteStimulatedneuronsChange in membrane potential AVmOutcome 1 Outcome 2 Outcome 30-30 mV15 mV0-15 mV-15 mVWhat is the interpretation of the above results?

Postsynaptic potentials are changes in membrane potential that occur due to the action of…

Identifying Neurotransmitters 3) Produces response in postsynaptic cell - Qualifying condition: Molecules evoking same response as neurotransmitters Presynaptic- terminal Postsynaptic drite Drug-containing micropipette Apply drug by passing electrical Current Stimulate axon Record V Drug application through the micro-pipette Stimulated neurons Change in membrane potential AVm Outcome 1 Outcome 2 Outcome 3 -30 mV 15 mV 0 -15 mV -15 mV What is the interpretation of the above results?

Identifying Neurotransmitters 3) Produces response in postsynaptic cell - Qualifying condition: Molecules evoking same response as neurotransmitters Presynaptic- terminal Postsynaptic drite Drug-containing micropipette Apply drug by passing electrical Current Stimulate axon Record V Drug application through the micro-pipette Stimulated neurons Change in membrane potential AVm Outcome 1 Outcome 2 Outcome 3 -30 mV 15 mV 0 -15 mV -15 mV What is the interpretation of the above results?

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 15P

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A loss-of-function mutation in the ion channel responsible for thegeneration of end-plate potentials results in a diminished permeabilityof the ion channel. 1) How would you experimentally test the effect of the mutation on thefunctional properties of the cell (synapse)? You should discuss the typesof postsynaptic responses and physiological parameters you couldmeasure.
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The giant axon of the squid (Figure Q11–3) occu-pies a unique position in the history of our understandingof cell membrane potentials and nerve action. When anelectrode is stuck into an intact giant axon, the membranepotential registers –70 mV. When the axon, suspended in abath of seawater, is stimulated to conduct a nerve impulse,the membrane potential changes transiently from –70 mVto +40 mV.
[Na*] [K*] This diagram is a drawing of normal conditions that occur in a neuron's axon (not all details are included). This stage that a living neuron would be in, would show that O no positive ions are inside the cell current is traveling down the axon O the cell will be at rest once the Na ions enter the cell O the cell is at rest O Na ions are predominantly outside the cell
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“All-or-none” response in impulse conductionmeans that
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