Can you match the type of mutations that can occur from the selected below? a. either proto-oncogene or tumor suppressor gene b. proto-oncogene c. tumor suppressor gen 1. Frameshift mutation 2. Missense mutation 3. Nonsense mutation
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Can you match the type of mutations that can occur from the selected below?
a. either proto-oncogene or tumor suppressor gene
b. proto-oncogene
c. tumor suppressor gen
1. Frameshift mutation
2. Missense mutation
3. Nonsense mutation
Step by step
Solved in 2 steps
- In what category of cancer-related genes is it possible to find inherited variants that are associated with cancer? Why? Group of answer choices 1. Tumor suppressor genes, because genes in this category are very important in the process of developing cancer. 2. Proto-oncogenes, because individuals who carry only one cancer-causing allele will have a wildtype phenotype. 3. Proto-oncogenes, because there are very few genes in this category, so mutations in them are rare. 4. Tumor suppressor genes, because individuals who carry only one cancer-causing allele will have a wildtype phenotype.Tumor suppressor genes and oncogenes are implicated in carcinogenesis. However, one can predict whether a gene potentially encodes for a protein that influences carcinogenesis by examining their mutational profile. You sequence the genome of 4 cancers and identify 3 genes of interest. Which of the following genes has the best potential to an oncogene? Tumor 1 Tumor 2 Tumor 3 Tumor 4 Gene A S24F, N465T R33T T345S, G366R P367E, P368Y Gene B S34R, F360I S34R V254I S34E, T67Y Gene C S24F, I322E C255I, E344D S34E, P367EWhy is it harder to develop a drug that targets a tumor suppressor gene compared to an oncogene (limit 3-4 sentences)?
- There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.Match the gene name with the gene description. rb BRCA-1 tumor suppressor А. p53 B. proto-oncogene В. Ras EGF ReceptorWhich of the following steps are correct about multistep tumorigenesis (select all that apply)? A. Mutations in progenitor cells are more likely to develop a neoplastic state compared to mutations in stem cells B. Driver mutations give a cell clone a proliferative advanage C. The rate of mutation /genetic change is constant during tumor progression D. Nutrition/diet may effect rate of tumorigenesis E. All cells within a tumor are biologically equivalent and equally capable of high levels proliferation
- Answer the following multiple-choice questions about cancer-promoting mutations. A gene whose mutant alleles function in a recessive way to predispose an individual’s cells to develop into cancer is called: A. a polymerase B. a proto-oncogene C. a tumor suppressor D. an oncogene EXPLAIN in 1-2 sentences:There are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA repair/stability genes. Distinguish between these three groups, then indicate which you think RB1 belongs to.P53 is a tumor suppressors protein. The protein is present in the cell at all times but is activated by protein kinases that are, in turned activated by DNA damage. A mutation of the P 53 gene in cell results in a form of P53 that is permanently active. What would happen to the mutant version of the P53 gene? Group of answer choices A. it would spread to neighboring cells but not very far B. it would be found in tumor cells only C. it would take over the world and make us all do its bidding D. it would only be found in the original cell in which the mutation occurred E. it would spread to all cells in the body
- The chapter points out that about one of every five women and one of every four men in the United States will die from cancer. Why arerates of death from cancer different in men and women? Provide some possible explanations. 3. A couple has one child with bilateral retinoblastoma. The mother is free from cancer, but the father has unilateral retinoblastoma and he has a brother who has bilateral retinoblastoma. a. If the couple has another child, what is the probability that this next child will have retinoblastoma? b. If the next child has retinoblastoma, is it likely to be bilateral or unilateral? c. Explain why the father’s case of retinoblastoma is unilateral, whereas his son’s and brother’s cases are bilateralPlease help me with the genomics/developmental biology question below: MatchingA. Proto-oncogenesB. Tumor suppressor genes1. _____ Include stimulators of CDK activity2. _____ Hypermethylation of these genes could contribute to tumor formationThe diagram shows the relative activity of a proto-oncogene and a tumor supressor gene in a normal cell, as well as the activity in four other cells. Normal cell A в D tumor suppressor gene proto-oncogene Which of these cells would be expected to be cancer cells? cell B cell D cell C cell A