Answer the following question about the synthesis: Intermediate 2 was formed by: H,N soCI, / Et,N (COCI), , DMF (solvent) но. OH Intermediate 1 Intermediate 2 THF (solvent)

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter17: Carboxylic Acids
Section: Chapter Questions
Problem 17.8P
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Answer the following question about the synthesis: Intermediate 2 was formed by:
H,N
SOCI, / Et,N
(COCI)2, DMF (solvent)
но
OH
Intermediate 1
Intermediate 2
THF (solvent)
N°
N
H
F
Meo
OMe
NH,
Mẹo
OMe
HN-
K2CO, / THF
O The acid is converted to the anhydride, then to the amide.
O The amide is formed directly.
O Converting the acid to an acid chloride, followed by formation of an amide.
O The acid chloride is formed first, and then the amine is formed.
Transcribed Image Text:Answer the following question about the synthesis: Intermediate 2 was formed by: H,N SOCI, / Et,N (COCI)2, DMF (solvent) но OH Intermediate 1 Intermediate 2 THF (solvent) N° N H F Meo OMe NH, Mẹo OMe HN- K2CO, / THF O The acid is converted to the anhydride, then to the amide. O The amide is formed directly. O Converting the acid to an acid chloride, followed by formation of an amide. O The acid chloride is formed first, and then the amine is formed.
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