a. Which gene is mutated in individuals with sickle-cell anemia? b. What are the major symptoms of this disorder? c. What was the first published scientific description of sickle-cell anemia? d. Describe two other features of this disorder that you learned from the OMIM database and state where in the database you found this information
a. Which gene is mutated in individuals with sickle-cell anemia?
b. What are the major symptoms of this disorder?
c. What was the first published scientific description of sickle-cell anemia?
d. Describe two other features of this disorder that you learned from the OMIM database and state where in the database you found this information
Hi! Thanks for your question. As you have posted multiple questions and have not mentioned which one is to be answered, we are answering only the first three questions for you. If you need help with the other questions too, please repost them separately.
A heritable genetic change in the genetic material of an organism that gives rise to alternate forms of any gene is called mutation. An organism which shows novel phenotype other than wild type phenotype, because of presence of a mutation in the genome, it is called a mutant. Gene mutation can occur due to many reasons, like change in chromosome number, chromosomal aberrations, chemical change in the nucleotide structure of gene, etc.
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