4. Look up chymotrypsin and answer the following questions? a) Where in the body is this made? b) What type of enzyme is it?
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- 8. Hypercholesterolemia is a frequent complication of diabetes mellitus in patients with prolonged hyperglycemia. Why a high level of glucose in blood causes hypercholesterolemia and atherosclerosis? For the answer explain: a) how glucose can interact with the proteins and the consequences of this reaction for the proteins; b) glycation of which proteins results in hypercholesterolemia; c) possible causes and complications of hypercholesterolemia.2. “Most enzymes are gene-encoded proteins." Using this lens, explain: A) effects of increased temperature on the rate of enzymatic reactions, and B) effects of decreased temperature on enzymatic reactions, and C) importance of optimal pH and ionic strength on enzymatic reactions.WHICH OF THE FOLLOWING ENZYME CAUSES TRIAD OF MENTAL CONFUSION , OPHTHALMOPLEGIA AND ΑΤΑΧΙΑ? А) VIT B1 в) VIT B2 с) VIT B6 D) VIT B12 E) VIT C
- Look up trypsin and answer the following questions? a) Where in the body is this made? b) What type of enzyme is it?23. Which is not a function of proteins: a) catalyzing reactions b) structural properties such as mechanical strength, shape, flexibility c) carries genetic information d) movement or contractionDi-isopropyl fluorophosphate is a(n) .................. inhibitor of chymotrypsin ? a) allosteric b) irreversible c) uncompetitive d) competitive e) mixed
- 4. The use of ATP to move substances across a plasma membrane of a cell occurs in a) facilitated diffusion b) simple diffusion c) osmosis d) active transport 5. Which of the following is NOT true concerning enzymes? a) they increase the rate at which a reaction proceeds b) enzymes are specific for their substrates c) enzyme names usually end with the suffix “-ase” d) since an enzyme is modified by a reaction, a given enzyme molecule can be used only once 6. DNA is replicated during what part of the cell cycle? a) S phase b) mitosis c) meiosis d) cytokinesis1) Answer the following questions about a Vegetarian diet: a) List Pros and Cons of being on the diet. b) List any possible misconceptions that may have been verified or nullified by scientific articles for this diet. c) What biochemical pathway would this diet target?. Based on what you know about enzyme inhibition, classify the following examples as irreversible, competitive, or noncompetitive enzyme inhibition. A) competitive B) noncompetitive C) irreversible 1) Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme. Paralysis results. 2) A drug binds to the active site of an enzyme but disassociates and leaves the enzyme active. 3) A toxin binds to the surface of an enzyme. The enzyme then binds the substrate, but no product is produced. The toxin may disassociate and the enzyme will become active again. 4) Vitamin K is a coenzyme involved in blood clotting. An anticoagulant drug binds at the site of vitamin K bonding, blocking vitamin K binding and preventing clotting. Clotting resumes after the patient stops taking the drug. 5) Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.
- 8. Patients on Irinotecan therapy increase production of hCES2 even though hCES2 breaks it down. (10.1093/inci/div132) Knowing this, How would you think about determining the optimum dosage of both drugs (Irinotecan and Compound 24) in a patient with chronic diarrhea/ulcerative colitis that is being treated for colon cancer? (There are a lot of right answers here). (Remember, Irinotecan and Compound 24 are BOTH binding hCES2).Penicillin and related drugs inhibit the enzyme _____; this enzyme is produced by _____. A) β-lacamase; bacteria B) lysozyme; human cells C) aldolase; bacteria D) transpeptidase; bacteria E) transpeptidase; human cellsIn what way(s) are Trypsin, Chymotrypsin, and Elastase different? (choose 1) a) They target different amino acid residues in proteins. b) They use different reaction mechanisms c) Both of the above d) Neither of the above