Let’s suppose you were interested in developing drugs to preventepigenetic changes that may contribute to cancer. What cellularproteins would be the target of your drugs? What possible sideeffects might your drugs cause?
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Q: Q7
A: Epigenetic changes include all except Change in DNA sequence. Epigenetic changes are modification in…
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A: Step 1- A gene is the essential physical and useful unit of heredity. Genes are comprised of DNA…
Q: Explain about the epigenetic differences ?
A: Introduction Expression of gene is highly under control by various mechanisms such as histone…
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A: Genomic imprinting is a process of silencing genes by the process of DNA methylation. The…
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A: A gene is that the primary physical and useful unit of heredity. "Genes" are created from…
Q: 1. Epigenetic marks refer to modifications to DNA and proteins that in tum regulate gene expression.…
A: Different macromolecules are present in humans. They include carbohydrates, lipids, proteins, and…
Q: CpG is an epigenetic term that means: Select one: a. The binding of cytosine with the following…
A: We know that, DNA is the genetic material of almost all living organisms. It is made up of monomers…
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A: Given, X is a cancer cell line which was treated with a drug Y. It resulted in the increase of…
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A: Epigenetics is the branch of genetics that studies heritable traits that are not influenced by the…
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A: Mutation, an alteration in the genetic material of a cell of a living organism or of a virus that is…
Q: What types of histone modifications are responsible for epigenetic phenotypes?
A: Histones are the set of positively charged proteins. Histones are responsible for providing…
Q: What DNA chemical modification can change the expression level of a target gene without sequence…
A: Introduction Epigenetics refers to the heritable or non-heritable changes in gene expression,…
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A: Mutation is defined as an erroneous change within the gene sequence of an organism that leads to a…
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A: A new multihit model of carcinogenesis is produced for use in assessing age-explicit disease rate…
Q: Which of the following is not a possible outcome of changing the epigenetic code? a) exposure of…
A: * Epigenetic code is an defining code in eukaryotic cells in which each cell consist specific…
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A: The cells are basic units of life. When any mutation in the gene takes place due to any radiation or…
Q: Epigenetic changes in gene regulation are caused by ________. missing nucleotides or chromosomes…
A: Epigenetic Epigenetic is a reversible change in the DNA which controls the expression of genes.
Q: What are epigenetic changes?
A: Epigenetics refers to the study of heritable changes in gene expression that do not involve changes…
Q: Is RNA silencing an environmentally-induced epigenetic change? Explain.
A: The regulation of gene expression via alterations to DNA, RNA, or histone proteins is known as…
Q: Are mutations good or bad? Explain your response to this question.
A: Any alteration in the sequence of deoxyribonucleic acid (DNA) is called a mutation. It occurs…
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A: A gene is a particular sequence of nucleotides in RNA or DNA that is generally located on a…
Q: Which of the following is NOT a description of an epigenetic modification? -The persistence of gene…
A: ANSWER;- Regulatory patterns that persist in the absence of the original signal. It is NOT a…
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A: Introduction: Gene is the structural and functional unit of inheritance or heredity which transfers…
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A: Cells are the basic structural, functional, and biological units of all living organisms. It is the…
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A: Pluripotent cells are capable of repeated division to form most or all of the cell types but cannot…
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A: Stem cell Stem cells are pluripotent cell that is produced by bone marrow cells.
Q: If p63 can bind to the same promoter elements as p53, why would it be considered an inhibitor of…
A: Promoters are DNA sequences that function as a kind of "On" switch to start the biological process…
Q: Define epigenetics and epigenetic silencing.
A: Introduction :- Epigenetics is the study of how your actions and environment can alter how your…
Q: What type of epigenetic changes are associated with cancer?
A: Epigenetic changes or modifications are important for maintenance of tissue specific gene…
Q: How can this identical set of genetic instructions produce different types of cells?
A: Genes are hereditary components that are located on the chromosomes. They can be passed on from one…
Q: What are enhancers and How do enhancers work?
A: Transcription is defined as the transcribing the DNA sequence into RNA sequence by using the DNA as…
Q: What is the rationale for synthesizing and rapidly degrading p53 protein in the cell?
A: P53 is a nuclear transcription factor with pro apoptotic function as 50% of human Kansas carries…
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A: Cancer cells are defined as the cells that will divide relentlessly and continuously; thus, forming…
Q: Why do mutations in genes that encode DNA-repair enzymes often produce a predisposition to cancer?
A: Cancer is the disease caused by loss of control over the process of cell division.
Q: Can you think of two ways in which the function of p53 can be disrupted?
A: P53 is a tumor suppressor gene which normally restrains growth and mutation in this causes loss of…
Q: How can mutations in noncoding segments of DNA contribute to the development of cancers?
A: The functions segment of hereditary material that mainly codes for the proteins is a gene. The…
Q: What are induced pluripotent stem cells? How are they derived from adult somatic cells?
A: Pluripotent stem cells are those cells that have the ability to renew themselves by dividing and…
Q: Epigenetic changes in gene regulation are caused by _ _ _ _ _ _ _ a. missing nucleotides or…
A: Epigenetics refers to both heritable and non heritable changes in gene expression that are not…
Let’s suppose you were interested in developing drugs to prevent
epigenetic changes that may contribute to cancer. What cellular
proteins would be the target of your drugs? What possible side
effects might your drugs cause?
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- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Explain in detail the main findings. Please sort as a list.Which of the following effectively describes the situation of someone with an inherited predisposition to cancer such as familial adenomatous polyposis or BRCA-associated familial breast cancer? Choose all that apply a) If they get malignant cancer, somatic mutations will not have been a factor b) Their cancer will most likely arise in their germ cells, not their somatic cells c) None of the answers effectively describes the situation d) Every cell of their body contains a gain-of-function allele of an oncogene e) Most cells in their body contain multiple cancer-causing mutations f) Every cell of their body contains a defective, loss-of-function allele of a tumor suppressor geneWhy is p53 considered a tumor suppressor protein? Question 12 options: a) Because p53 normally detects breaks in DNA. b) Because p53 normally causes progression from G1 to S phase to halt until damaged DNA is fully repaired. c) Because p53 normally repairs breaks in DNA. d) Because p53 normally stimulates transcription of Repair Polymerase. e) Because p53 normally reduces the mutation rate of DNA polymerase.
- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please list item by item. Explain in detail the main findings.one question with multiple parts! 1A) If you were a cancer biologist interested in developing new drugs that will slow down cancer cell metastasis, which of the following strategies would be most effective? a)Develop an activator of mitosis b)Make Her2 protein that is more active on the surface of the cancer cells c) Develop a molecule that increases telomerase activity d) Gene therapy to add a mutated p53 gene to the cancer cells 1B) You are a genetic counsellor, and a couple comes to you with concerns that if they have a child together the child could have the X-linked recessive disease Duchene muscular dystrophy. The man has the disease whereas the woman is a carrier. Which of the following would be a true statement to tell them? a) 100% of their male offspring will likely be carriers of the recessive allele that causes the disease b) 75% of their female offspring will likely be carriers of the recessive allele that causes the disease c) 100% of their male offspring will likely…What separates cancer cells from normal cells? Describe one form of mutation that can increase the risk of a normal cell being cancerous.
- Which of the following mutations is MOST likely to cause cancer? A) a mutation that causes a cyclin gene to be expressed at all times during the cell cycle B) a mutation that causes an oncogene to be turned off so that no protein is made C) a mutation that causes a Cdk gene to be turned off so that no protein is made D) a mutation that causes a tumor suppressor gene to be over-expressedD) The level of carbon dioxide increases with the level of available oxygen. 60) The TP53 gene provides instructions for making a protein called tumor protein p53. Known as the guardian of the genome, this protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches directly to DNA and plays a critical role in determining whether the DNA will be repaired or the damaged cell will self- destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. eg Suppose chromosomes in a skin cell are damaged by ultraviolet radiation. If the damaged genes do not affect p53, which choice correctly predict if the cell will become cancerous and why? No, the cell will…What is the difference between a proto-oncogene and a tumor-suppressor gene?
- Why is it important to model cancer through the generation of induced pluripotent stem cells ? Please explain in detailsSuppose a gain-of-function mutation happens in an oncogene. Which of the following changes is likely to result? O a) tumor-promoting inflammation O b) evading growth suppressors Oc) sustaining proliferative signalling O d) resisting cell deathWhich of the following is true of tumor suppressor genes? Group of answer choices a) If this gene is overactive, it becomes an oncogene b) If one of the alleles is mutated, there is usually little effect. Two inactivating mutations are usually required for loss of function (recessive mutation). c) If one copy is lost, the gene no longer functions (dominant mutation) d) Tumor suppressors genes usually cause mitosis or cell growth e) Tumor suppressor genes decrease apoptosis