In the salvage of purines, hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is responsible for which of the following processes? Conversion of hypoxanthine to xanthine Conversion of adenine to adenosine monophosphate (AMP) Conversion of guanine to guanosine monophosphate (GMP) Conversion of inosine monophosphate to inosine
Q: A metal object with mass of 25.0 g is heated to 97.0 °C and then transferred to an insulated…
A: The objective of this question is to calculate the specific heat of a metal object. The specific…
Q: 1. For each of the following molecules, determine the absolute configuration at every chiral…
A: In organic chemistry, a chiral center is a carbon atom that has four distinctive groups joined to…
Q: Identify ALL products expected from this reaction. Bonus question (for class): Draw the products…
A: The overall reaction of Oxymercuration-demercuration involves addition of water molecule to alkene…
Q: Balace each chemical equation HI (aq) + O2 (g) ----> H2O(1) + I2(s)
A: Answer:The Law of conservation of mass states that mass cannot be created nor destroyed. That's why…
Q: How many stereoisomers exist for the following compound? It is helpful to draw them all out in…
A: A pair of substances which are non-super imposable mirror images are called enantiomers.A pair of…
Q: Draw the electron-rich and electron-poor compounds that reacted together to form, after aqueous…
A: The objective of the question is to identify the electron rich and electron poor compounds.
Q: A mixture of hydrocarbons contains 37.0% heptane, CH16, 14.7% nonane, CH₂, and 48.3% octane, CH₁.…
A: given:Mixture contains 37.0% heptane, 14.7% nonane, and 48.3% octane.Mass of mixture = 14.9…
Q: At 1000 K, Kp =2.1 x 10° and AH = -101.7 kJ for the reaction H2 (g) + Br2 (g)=2HBr (g). Part A A…
A: Given ,
Q: Sulfur dioxide, SO2(g), can react with oxygen to produce sulfur trioxide, SO3(g), by the reaction…
A: Given data:Volume of gas = 4.10 LPressure of gas = 1 barTemperature = 25o CFormula used:
Q: This experiment will use a technique known as neutron activation analysis (NAA) to determine the…
A: The objective of the question is to determine the number of neutrons in the nucleus of a 20F…
Q: Need for CLF3. CHECK OTHER IMAGE FOR SAMPLES I NEED LIKE THIS SOLUTIONS OK. OTHER IMAGE I NEED…
A: Lewis structure shows the relative distribution of bond pairs and lone pairs present in the…
Q: Determine the number of grams of NH Br needed to prepare an aqueous solution at a specific pH by…
A:
Q: 2. Provide the structure of the intermediates and products for the following reactions. (a) (b) CH3…
A: Hydroboration-oxidation of alkenes:Alkenes on hydroboration with boron hydride gives organoboranes,…
Q: HO HO 。།ཙཱ་
A: An arrow always depicts from a region of high electron density to low electron density ; that is…
Q: how do I calculate the standard deviation of these values?
A: The objective of the question is to calculate the standard deviation of the given set of values and…
Q: For the NMR spectrum shown below", draw the structure of the reactant next to the spectrum and label…
A: The given compound is 4-aminobenzoic acid. The IR and NMR spectrum of this compound also given.…
Q: Ammonia will decompose into nitrogen and hydrogen at high temperature. An industrial chemist…
A: The reaction considered is decomposition of ammonia to nitrogen and hydrogenThe initial pressure of…
Q: 2. Predict the product(s) that forms and explain why it forms. Assume that any necessary catalytic…
A: An arrow always depicts from a region of high electron density to low electron density ; that is…
Q: Please don't provide handwriting solution
A: The lowest energy conformation for the given compound is the option 1.Explanation:In the given…
Q: i: increase or decrease? ii:①0.01/0.02/0.03/0.04/0.05/0.06 ②0.01/0.02/0.03/0.04/0.05/0.06/0.07…
A: i) Increasesii) 1. 0.032. 0.043. 0.01Explanation:
Q: In one trial of this experiment, graphing Ecell against ln Q for a series of copper/copper(I)…
A: The objective of the question is to calculate the value of the ideal gas constant.
Q: Draw the molecular orbital (MO) electron diagram for the N2 molecule. Be sure your diagram contains…
A: Molecular orbital diagram for molecules which contain total electrons equal to or less than 14 can…
Q: Print the three unrotated sp2 hybrid orbitals. Do these demonstrate the expected geometry needed for…
A: In the given question we have to draw the sp2 hybrid orbitals needed in the formation of bonds in…
Q: Calculate the pH at 25 °C of a 0.20M solution of pyridinium chloride (C,H,NHC1). Note that pyridine…
A: Information about the question
Q: At a certain temperature, the equilibrium constant K for the following reaction is 8.1 × 1010 :…
A: Given ,Reaction :
Q: Complete the table: Element Mass Moles Number of Atoms Na 45.5 mg C 1.56 212 V Hg 1.16 kg
A: Atomic mass of Na = 22.99 g/molAtomic mass of C = 12.01 g/molAtomic mass of V = 50.94 g/molAtomic…
Q: Which of the statements most accurately describes the following electron configuration? 1 b 1 a. It…
A: The objective of the question is to identify the correct option.
Q: i:2.5/4.0/0.25/0.4 ii:6.25/75/25/100/50 iii:25/50/75 iv1:4/0.2/0.75/0.25 iv2:8/10/20/30/40
A: 1. 0.252. 100ml3. 75ml4a. 0.24b. 8%Explanation:
Q: The reaction A → products is second order. If the initial concentration of A is 0.436 M and,…
A: see attachmentExplanation:Step 1: Step 2: Step 3: Step 4:
Q: Starting from the wedge-and-dash structure below (sighting down the dicated bond), rotate the back…
A: The step-wise stereochemistry is discussed belowOptical activity is defined as the reaction of…
Q: Give the structure of the product from Step 2. Be sure to include all lone pair electrons and formal…
A: 1. PCC: Pyridinium chlorochromate: It is a mild oxidizing agent.This is used to oxidise primary…
Q: 3 N,N-Dimethylpropionamide 9 CH2 = CH -CH, CHO - 5 NO₂ W NO 2 Phenol ⑦3-hydroxy-4-methylhexanoic…
A: IUPAC Rules for the nomenclature of the branched organic compoundsFirst we should select the longest…
Q: Exp. # [I] log[I] [Fe 3+] log[Fe 3+] A [Fe 3+] At (sec) Rate law log R k Temp. 1 4.0 X 10 -3 -2.40…
A: To determine the average value of k, you need to calculate the rate constant for each experiment…
Q: Draw the structure of all products of the mechanism below. :CI: :0: + H₂C-C―OCH₂ Al Click and drag…
A: Final answer is given in explanation please see from there.Explanation:Approach to solving the…
Q: Write the rate expression in terms of reactants and products for the following reaction. What is the…
A: Rate of a reaction is defined as the decrease in concentration of reactant in unit time (Or)…
Q: 2. Show a reaction sequence to convert oil of wintergreen (methyl salicylate) into Aspirin (acetyl…
A: Methyl salicylate is a compound contains a hydroxy group and an ester group. Aspirin ( acetyl…
Q: In a study of the formation of HI from its elements, H2(g) + 12(g) = = 2HI(g) equal amounts of H2…
A: Initially, both H2 and I2 concentrations decrease as they react to form HI, so their concentration…
Q: Answer the questions in the table below about this molecule: O о HẠN—CH−C−NH-CH-C-NH–CH-COO CH2 CH…
A: Peptide:A peptide is a short chain of aminoacids (typically 2 to 50) linked by chemical bonds…
Q: Use the following atomic weights and quantities to calculate the overall % yield of benzopinacol.…
A: % yield of Benzopinacole is 10.13 % Explanation: Mass Benzophenone = 38.103 gMass of Isopropanol…
Q: Current Attempt in Progress Incorrect. Identify the major and minor products for the E2 reaction…
A: The major and minor product of the reaction can be determined via the following…
Q: Please don't provide handwriting solution
A: 1st structure has lowest energy Explanation:Step 1:Correct answer is option 1st . In the context of…
Q: In cationic rearrangements like the pinacol reaction, migrating hydrogens and alkyl groups are shown…
A: The question is asking us to identify the type of reaction mechanism that describes the migration of…
Q: What is the relationship between the following two molecules? a. Enantiomers b. Constitutional…
A: The objective of the question is to find the relationship between the two given molecules from the…
Q: I'm needing help with creating the graph using the Time-Tempeature Data sheet from those trails 1…
A: Specific heat: It is the amount of heat required to raise the temperature of 1 gram of substance by…
Q: According to the text, for each pinacol rearrangement below, followed by alkaline degradation, which…
A: Chcek belowExplanation:
Q: 16. What is the index of hydrogen deficiency (or degree of unsaturation) of the following molecule?…
A: Degree of Unsaturation Formula:We also know it by the name of the index of hydrogen deficiency…
Q: How many moles of potassium nitrate equal 8.68 × 1020 molecules of KNO3? 0.00144 mol 694 mol 6.94…
A: In order to determine the quantity of moles of potassium nitrate (KNO3) based on the provided number…
Q: 2. Predict the product(s) that forms and explain why it forms. Assume that any necessary catalytic…
A: Since you have posted a question with multiple questions, we will provide the solution only to the…
Q: Draw a complete lewis dot structure(showing all atoms,bonds,ione pairs, and charges) of the…
A: We have to draw the Lewis dot structure of nucleotide DEOXYCYTIDYLATE.
Q: Set up simultaneous equations for the analysis of Mo, Ti and V mixture by the peroxide method, using…
A:
Step by step
Solved in 3 steps
- Thiopurine S-methyltransferase (TPMT) is an enzyme that is responsible for the metabolism of the drugs azathioprine and 6-mercaptopurine, which are used to treat acute lymphoblastic leukemia and inflammatory bowel disease. Metabolism by TPMT reduces the bioavailability of the drugs. In addition to the thiopurine substrates, TPMT also binds S-adenosyl methionine as a cofactor. TPMT is a highly polymorphic enzyme; almost 30 variants are known to be expressed in humans, with most of the variants possessing lower enzymatic activity than the wild-type protein (TPMTwt). Despite having substitutions remote from the active site, TPMT*2 (an A80P variant) and TPMT*5 (an L49S variant) have enzyme activities of 47% and 14% relative to TPMTwt at 18°C, respectively. Two techniques were used to understand the relationships between enzymatic activity and protein stability. Circular dichroism (CD) spectroscopy measures the differential absorption of left and right-circularly polarized light and is used…Diisopropylphosphofluoridate (DIPF) inactivates chymotrypsin by covalently modifying serine 195. Which statement is true of DIPF's inhibitory mechanism? DIPF randomly modifies all serine residues on the protein, and if enough is added, the serine in the active site will eventually be modified. DIPF approaches serine 195 more closely than other substrates. DIPF looks like the substrate for chymotrypsin and binds in the active site as a competitive inhibitor. Serine 195 is in an environment that gives it a higher than normal reactivity with respect to DIPF.Why is de novo biosynthesis of purines markedly elevated in patients with a deficiency in hypoxanthine-guanine phosphoribosyl transferase (HGPRT)? 5-Fluoruracil is converted to methotrexate by a DPD deficiency, leading to increased purine biosynthesis. HGPRT deficiency prevents purine salvage, leading to increased purine biosynthesis to make up for it. HGPRT increases pyrimidine salvage and thereby increases purine biosynthesis as a result. Increased purine biosynthesis is the result of ATP hydrolysis during the production of cyclic AMP.
- Which of the following about adenosine triphosphate (ATP) is FALSE? A) There are two phosphoanhydride bonds with similar energies B) ATP can be used as a substrate to make cyclic AMP (cAMP) after a cell has been stimulated with certain specific hormones C) The γ-phosphate can be transferred (e.g. to chemical group on a protein enzyme) such as the Na+-K+ pump, which is part of a coupling mechanism that allows otherwise unfavourable reactions to proceed No possible answer provided E) The large, negative, free-energy change upon hydrolysis of “high-energy” compounds like ATP is partly due to the creation of resonance stabilized productsYou have isolated a new protease that cleaves peptide bonds on the carboxyl side of Asp and Glu. Based on the enzyme's inactivation by DIPF, you suspect that it may utilize a mechanism similar to chymotrypsin. The difference in specificity might be explained by the absence of the S1 binding pocket. replacement of serine 195 with a positively charged residue. presence of a positively charged residue in the S1 binding pocket. presence of a negatively charged residue in the S1 binding pocket.Folic acid is synthesized in bacteria as dihydrofolate, in a pathway starting from guanosine triphosphate. In this pathway, C-8 is lost as formate. From the structural similarities between guanine and pterin, predict which carbon and nitrogen atoms of GTP are the precursors to N-1, C-2, C-4, N-5, C-7, N-8, and C-9 of dihydrofolate.
- When hyaluronan synthase from Pasteurella multocida was expressed in E. coli, the bacteria spun out a capsule of hyaluronan. This reaction was analyzed using purified membrane fragments containing the hyaluronan synthase, a radio-labeled tetrasaccharide acceptor (Part A), along with the activated forms of the sugar subunits: UDP-N-acetylglucosamine and UDP-glucuronic acid. In short incubations with the complete mixture, the tetrasaccharide primer elongated by several units, although only odd-numbered chains were visible (Part B lane 2). If one or both activated sugars were left out, the results shown in lanes 3-5 (Part B) were obtained. Why do you suppose that only odd-number chains are visible in your assay? (A) ACCEPTOR nonreducing end HO- HO OH COO glucuronic acid (GICUA) HO- CH3 T C=O I NH CH₂ OH N-acetylglucosamine (GlcNAc) COO но- HO OH OH I CH₂ reducing end NH C=O CH3 Choose one: O A. Synthase adds GlcNAc much more slowly than it adds GICUA. O B. One of the monosaccharide…Peroxidase is an enzyme found in many organisms, from plant to humans. The function of peroxidase is to break down hydrogen peroxide, which is a toxin produced as a byproduct when oxygen is produced during respiration. Myeloperoxidase is a protein found in neutrophils and catalyzes lipid peroxidation involved in immune defense. The overproduction of myeloperoxidase has been found to function as a mediator for tissue damage in inflammatory diseases. (8 points) a. Identify two examples of environmental factors that may impact myeloperoxidase activity. Describe how each of the environmental factors would affect the reaction rate of the enzyme. b. Predict the how researchers can use myeloperoxidase activity as oxidative stress biomarkers in patients with rheumatoid arthritis. Provide reasoning to justify your prediction.ATP synthase is a protein that catalyzes the formation of the energy storage molecule adenosine triphosphate using adenosine diphosphate and inorganic phosphate. Which of the following are true for the protein, ATP synthase? Select all apply A mutation of Asp61 to glutamic acid would have less of a deleterious effect on its ability to synthesize ATP than a mutation of Asp61 to alanine A mutation of Asp61 to alanine would have less of a deleterious effect on its ability to synthesize ATP than a mutation of Asp61 to glutamic acid The F1 subunit is primarily responsible for translocating H+ ions across the inner mitochondrial membrane during ATP synthesis The FO subunit is primarily responsible for translocating H+ ions across the inner mitochondrial membrane during ATP synthesis
- Some bacteria contain three different forms of aspartokinase, each with its own mode of regulation. Based on the roles of aspartoki- nase, as discussed in the text, propose a regulatory scheme applicable to each form of aspartokinase.A bacterial lactose transporter, which is highly specific for lactose, contains a Cys residue that is essential to its transport activity. Covalent reaction of N-ethylmaleimide (NEM) with this Cys residue irreversibly inactivates the transporter. A high concentration of lactose in the medium prevents inactivation by NEM, presumably by sterically protecting the Cys residue, which is in or near the lactose-binding site. You know nothing else about the transporter protein. Suggest an experiment that might allow you to determine the Mr of this Cys-containing transporter polypeptide.d) Alcohols usually don't behave as a weak acids, but tyrosine does. Explain why Y ionizes, while S and T do not. e) Is Y ionization physiologically relevant? Explain. f) Y is capable of being phosphorylated by kinases in vivo. What mutation might you introduce to render Y unphosphorylatable? Constitutively phosphorylated?