Does the allosteric regulation induced by insulin activate (or repress) phosphofructokinase-1 activity?
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Q: antagonistic Hormone Explain why insulin and glucagon are considered antagonistic hormones?
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Q: Explain the functions of insulin. Why do you think a hormone such asinsulin is required to carry out…
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Q: How is it possible that both insulin andepine phrine stimulate muscle glycolysis?
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Q: Given the effects of glucagon on plasma glucose concentrations, what effect do you think…
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Q: What are the drawbacks of the insulin obtained from the slaughtered cows and pigs?
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Q: Describe the negative feedback between Insulin and Glucagon
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Q: What are the steps involved in synthesis of genetically engineered insulin.
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Q: Which metal is present in Insulin?
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Q: What are the targetorgans upon which insulin andglucagon act?
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Q: How the insulin is tagged and stored for the cell membrane ?
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Q: Explain why insulin can stimulate the activation PKB of but not the activation of PK.
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Q: Predict the biochemical and whole body effects of an overdose of insulin
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Q: Name two proteins that are effectors of the insulin signaling pathway in adipocytes, liver, or…
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Q: What pathway in addition to the cAMP-induced signal transduction pathway is used in the liver to…
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Q: Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations…
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A: PKB stands for protein Kinase B is defined as serine or threonine-specific protein kinase that will…
Q: What is the second messenger for the insulin response? What is the link between insulin binding to…
A: Insulin is considered a peptide hormone, which helps in the growth and proliferation of the cell.
Q: What is the biochemical basis of insulin resistance?
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Q: Which of the following is FALSE about Insulin?
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Q: Ketoacidosis is a common feature of insulin-dependent diabetes mellitus, but not insulinindependent…
A: Diabetic ketoacidosis is a condition occurs when body is not able to produce enough insulin to…
Q: What is the second messenger for the insulin response?
A: The molecular pathways for insulin's signal transduction from its cell surface receptor to the…
Does the allosteric regulation induced by insulin activate (or repress) phosphofructokinase-1 activity?
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- What is the full regulatory pathway of glycogen synthase and glycogen phosphorylase by insulin and the GPCR pathway?Glycogen synthase in the liver is a target for phosphorylation by two protein kinases. What are these two protein kinases and how are they independently regulated by glucagon and insulin to regulate glycogen biosynthesis?How do insulin and epinephrine regulate glycogen metabolism in the muscle through the Glycogen targeting protein GM?
- The Gq-protein and phospholipase C pathway are responsible for stimulating gluconeogenesis and glycogenolysis. What effect would an agonist or an antagonist have on gluconeogenesis and glycogenolysis?Compare the localization of GLUT4 with that of GLUT2 and GLUT3, and explain why these localizations are important in the response of muscle,adipose tissue, brain, and liver to insulinFatty acids appear to stimulate insulin secretion to a much greater extent when glucose is also present. Why is this significant?
- 64 An investigator is studying the mechanism of action of an insulin-sensitizing drug. The addition of the drug to cultured mouse hepatocytes is observed, and results show increased phosphorylation and inhibition of acetyl-CoA carboxylase Which of the following processes is most likely inhibited by this action of the drug? A) Fatty acid oxidation B) Fatty acid synthesis C) Glycogen synthesis D) Glycolysis E) Protein synthesisHow does glucose binding to glycogen phosphorylase stimulate glycogen synthesis?Which TCA component is syphoned off to increase glucose production via gluconeogenesis when glucose consumed levels are low?
- What pathway in addition to the cAMP-induced signal transduction pathway is used in the liver to maximize glycogen breakdown?Is AMP an allosteric inhibitor or activator of glycogen phosphorylase in the muscle or liver?Why does it make metabolic sense for the same hormone signal to stimulate glycogenolysis and inhibit glycolysis in the liver while stimulating both glycogenolysis and glycolysis in muscles?