Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer?
Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells. Which drug is most likely to help treat this patient's cancer?
Essentials of Pharmacology for Health Professions
7th Edition
ISBN:9781305441620
Author:WOODROW
Publisher:WOODROW
Chapter14: Antineoplastic Drugs
Section: Chapter Questions
Problem 11CRQ
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Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes (including many cancer-causing genes). Scientists determine that the histones from the cancer cells have an overall/average lower affinity for DNA than histones from normal control cells.
Which drug is most likely to help treat this patient's cancer?
a. An inhibitor for HMT (histone methyltransferases)
b. An inhibitor for HDM (histone demethylases)
c. An inhibitor for HDACs (histone deacetylases)
d. An inhibitor for HATs (histone acetyltransferase)
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