A original pedigree: 8 alleles 3 78 13 1 2 12 34 34 5 6 23 56 7 8 9 10 11 12 37 17 26 25 36 35 Using the same pedigree as the last question (included above), how many recombinant individuals are in the pedigree when testing the linkage between the disease and the marker (i.e. the alleles listed below each shape)? 1 recombinant 3 recombinant 5 recombinant O recombinant
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- Normal wife Affected husband As a genetic counsellor you are presented with a married couple where one of them has a family history of this disease. The husband is affected by this disease and the wife is normal. The couple, who are thinking of starting a family, would like to know what their chances are of having a child born with this condition. They would also like to know what the probabilities are of having an affected boy or affected girl. Use the symbols above to complete the diagram right and determine the probabilities stated below (expressed as a proportion or percentage). Parents 4. Determine the probability of having: Gametes (a) Affected children: Possible (b) An affected girl: fertilizations (c) An affected boy: O O O O Children Affected aite if 耳In a cross between mice the genotypes AB/ab x ab/ab, what is the recombination frequency if the progeny numbers are 72 AB/ab, 68 ab/ab, 17 Ab/ab, and 21 aB/ab? The alleles are shown for each chromosome, separated by a slash (/)GsnKivd010j2gIRWLIZOMZZ-VibKYvBbo61ylATAQ/viewform RECOMBINATION". For numbers 7-35, reler to the given data below. Glven the following testcross data for com In whlch the genes for fine stripe (f), bronze gleurone (bz) and knotted leaf (Kn) are involved: + = wild type f fine stripe +=wild type bz = bronze gleurone +=wild type Kn knotted leaf %3D Genotype Ko f Number 451 Ko 134 97 436 bz bz bz Ko 18 119 f 24 Kn f bz 86 Total: Your answer 7-8. What would be the recombination frequency or the frequency of the recombinant type between +/Kn and +/f genes? Oa. 16% O b. 16 map units + + + + +
- The recombination frequency in a cross can never exceed 50%. Explain why is this limit?Phenotype chr1.1 chr2.8 chr3.12 chr4.12 chr4.55 chr7.88 chr9.55 chr10.1 chrX.1 chrX.5 Purple AA AT Purple AA AT F F GG GC 80 CC CC TT TT TT CT 80 CC CC AT TT TT CT 8 CC CC AT AT GG CT GC TT CC AT AT GT 10 CT Yellow AA AT TT GC Purple and AA TT Yellow F Purple AA AT AA GG TT GC AT TT TT CT Purple AA AT AA GG TT GC AT TT TT CT Purple AA AT AA Purple AA AT AA 80 CC TT GG AT TT TT TT 646 GG CC GG AT TT TT TT Purple and AA TT AT CC 80 Yellow 80 CC GG AT AT GT TT Purple AA AT AT CC CC GC AT F TT TT TT E Purple AA AT AT CC TT GC AT TT TT CC Purple AA AT E 00 CC TT GG AT TT TT CC Yellow AA AT AT GC TT 00 CC AT AT GG CC 80 TT E AT AT GC CC CC AT AT GG TT Yellow AA AT AT GG CC CC AT AT GG Yellow AA ধ 80 CC CC AT AT GT TT GG TT GG AT AT GG TT Purple and AA AA AT GG Yellow Yellow AA AA F 80 CC GG AT TT TT CC 80 GC CC GG AT AT GT CC Purple AA AA AT GC Purple and AT AA Yellow Purple AA AA F F GG 80 CC GG AA TT GT CCAssuming both hemophilia and red-green colorblindness are rare traits, who is recombinant in generation III? (Select all that apply.) Male 甲 Female I Hemophilia A O Hemophilia B %3D Color-blind Hemophilic and color-blind None IlII-3 male III-1 male III-2 male III-4 male
- The results of a paternity test using short tandem repeatsare listed in the table below. Who’s the daddy? How sureare you?A blood stain from a crime scene and blood samples from four suspects were analyzed by PCR using fluorescent primers associated with three STR loci: D3S1358, vWA, and FGA. The resulting electrophoretograms are shown below. The numbers beneath each peak identify the allele (upper box) and the height of the peak in relative fluorescence units (lower box). Solve, (a) Since everyone has two copies of each chromosome and therefore, two alleles of each gene, what accounts for the appearance ofonly one allele at some loci? (b) Which suspect is a possible source of the blood? (c) Could the suspect be identifi ed using just one of the three STR loci? (d) What can you conclude about the amount of DNA obtained from Suspect 1 compared to Suspect 4?Which of the following terms means many genes? polymorphism polygeny polypeptide multiple alleles
- Pedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?Pedigree Analysis Is a Basic Method in Human Genetic: What does OMIM stand for? What kinds of information are in this database?The recombination process below occurs when two recombination occurs between two different alleles, but only only one of the alleles is perpetuated in the final product. This process is called [x]?