18. 2-Aminopyridine can be nitrated or sulfonated under much milder conditions than pyridine itself; substitution occurs chiefly at the 5-position. Account for these facts. 19. Ethyl bromosuccinate, I, is converted into the unsaturated ester ethyl fumarate, II, by the action of pyridine. What is the function of the pyridine? What advantage does it have over the usual alcoholic KOH conditions? ethyl fumarate ethyl bromosuccinate

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18. 2-Aminopyridine can be nitrated or sulfonated under much milder conditions than pyridine
itself; substitution occurs chiefly at the 5-position. Account for these facts.
19.
Ethyl bromosuccinate, I, is converted into the unsaturated ester ethyl fumarate, II, by the
action of pyridine. What is the function of the pyridine? What advantage does it have over
the usual alcoholic KOH conditions?
BEE
OEI
OEt
OEt
OEL
ethyl fumarate
ethyl bromosuccinate
Transcribed Image Text:18. 2-Aminopyridine can be nitrated or sulfonated under much milder conditions than pyridine itself; substitution occurs chiefly at the 5-position. Account for these facts. 19. Ethyl bromosuccinate, I, is converted into the unsaturated ester ethyl fumarate, II, by the action of pyridine. What is the function of the pyridine? What advantage does it have over the usual alcoholic KOH conditions? BEE OEI OEt OEt OEL ethyl fumarate ethyl bromosuccinate
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