. a. Compare the means by which retroviral and AAVvectors deliver therapeutic genes to human cells.b. Explain the advantages and disadvantages of eachof the two viral vectors.
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. a. Compare the means by which retroviral and AAV
vectors deliver therapeutic genes to human cells.
b. Explain the advantages and disadvantages of each
of the two viral vectors.
Step by step
Solved in 3 steps
- discuss the benefits and limitations of using a retroviral system or an adenovirus for the delivery of a therapeutic gene.Describe problems associated with the use of viralvectors to introduce therapeutic genes into the cellsof patients.Discuss the advantages and disadvantages of the use of the following viruses as vectors a. Retroviruses b. Adenoviruses c. Adeno-associated viruses
- n the "Vaccine Strategies" figure, multiple vaccination options are presented. Select all options below which are options under consideration for the COVID-19 vaccine. A). Injection of a weakened virus B). Injection of an inactive virus. C). Injection of a related coronavirus. D). Injection of genetic material to produce viral proteins directly in the cell.(c) Molnupiravir has not been approved but has been authorized for emergency use by the FDA under an EUA to treat mild to moderate COVID-19 infection. Briefly explain this decision made by FDA based on the knowledge of clinical trials. (d) Both drugs are not allowed to be prescribed to person under 18 years old due to insufficient clinical data. Why is it necessary to separately conduct clinical trials for a younger age group?What are the different methods for developing modified release drug delivery system ? Discuss about the matrix and encapsulation drug release systems. Please explain at your own words.
- Suggest different strategies on the following aspects of COVID-19: a. Diagnostics b. VaccinesAntiretroviral drugs target various aspects of HIV replication and infection. Which of the following enzymes are targets of antiretroviral drugs? Select ALL that applya).reverse transcriptaseb)integrasec).ligased).proteasee).DNA polymeraseAside from antibody-producing vaccines against spike proteins, describe at least 2 other therapeutic strategies that employ knowledge of pathways allowing viral entry into cells and/or mechanisms preventing replication of new viral particles after entry.
- Biotransformation is an important concept in pharmacology, which amongst others, enables the effective administration of prodrugs. Provide a detailed description of factors influencing the biotransformation of drugs.b) Explain how the chimpanzee adenovirus has been genetically modified and developed as a viral vector to deliver the Oxford-Astrra Zenica Covid 19 vaccine (ChAd0x1nCoV-19/AZD1222). Include how the vaccine was developed, trialled, how the vaccine works and why a booster is needed.List the main steps of PGT-M approach and explain its main differences than PGT-A.