The mouse thymus normally contains about 1–2 ´ 108 thymocytes, the vast majority of which are CD4+CD8+ (double-positive) cells. When thymocytes from mice with a gene deficiency in the TCRa locus are compared with those from TCRb-deficient mice, a striking difference between the two different knockout lines is observed, as shown in the figure below in a simplified version of flow cytometry data. The numbers of thymocytes in each thymus is indicated below the plots. What is the explanation for the difference in thymocyte subsets and cell numbers observed when comparing TCRa-/- to TCRb-/- thymocytes? Which region of the thymus organ would show a dearth of developing thymocytes in the TCRa-/- thymus? Which

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Genomic studies

Genomic studies (genomics) is the study of the whole genome of an organism. Using bioinformatics and high-performance computing, genomic researchers examined massive amounts of deoxyribonucleic acid (DNA)-sequence data to discover variations or mutations that affect drug response, health, or disease. Genomics is a much younger discipline than genetics, having only emerged in the last few decades as a result of technological advancements in DNA sequencing and computational biology.