Question 15Which of the following statements is NOT true about GWAS?O When identifying alleles associated with a disease, we compare the frequency of an allele in a control group versus a case group.O When doing a GWAS, you often find groups of SNPs having a strong correlation with the phenotype of interest.O When doing a GWAS, we often test only a few alleles of interest.O When looking for alleles associated with a continuous trait we test for an correlation between the trait and each possible genotype.Question 16There are several drawbacks to doing a GWAS. Which one is FALSE?O Care should be taken that the environment is either constant, or at least evenly randomized among samples.OAGWAS only finds allelic associations, and not causation.OA lot of complex traits are largely determined by the environment, and genetics can only explain a small percentage of variation.OA GWAS can only test for a small number of genetic variants.

Detailed explanation:1) a) When identifying alleles associated with a disease, we compare the…

Answered: Question 15 Which of the following…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Question 11 What statement is FALSE regarding the use linkage mapping for human genetics? O The first linkage map showed the relative location of genetic markers. OA large number of chromosomes means that many traits assort independently, frustrating linkage mapping efforts. O Linkage mapping continues to be the preferred method to determine alleles associated with disease. Initial linkage mapping used family pedigrees. Question 12 Which of the following is not a component of Sanger sequencing?
Question 9 Which of the following statements about Genome-wide association studies is NOT true? O A genome-wide association study is an approach that involves testing genetic variations in the genomes of many people to find genetic variations associated with a particular disease. O When DNA variations are linked to a trait through a genome-wide association study, they always exhibit an autosomal recessive inheritance pattern. O Genome-wide association studies are useful because they can identify alleles that have small effects on multifactorial traits. O Genome-wide association studies only became possible in the past 5-10 years when methods such as SNP-chip and whole genome sequencing were invented.
QUESTION 1) The vocal properties of the shrieking eels of Florin are controlled by three genes. The dominant alleles, L (loudness), P (pitch) and T (timing) cause eels to emit loud, high-pitched shrieks in the morning. The recessive alleles (I, p, and t) cause eels to sing softly, at a low pitch, in the evening. In a three-point linkage analysis experiment, I carried out a test cross using a triply heterozygous eel and a triple recessive partner. When the eggs hatched, I found that the resulting 8000 offspring had the following phenotypes i) Loud, high pitch, morning 160 ii) Loud, high pitch, evening 690 iii) Loud, low pitch, evening 3000 iv) Loud, low pitch, morning 10 v) Quiet, high pitch, morning 3360 vi) Quiet, high pitch, evening 30 vii) Quiet, low pitch, evening 240 viii) Quiet, low pitch, morning 510 Calculate and draw the genetic map for the genes L, P and T including distances. (THE NUMBERS ARE VERY SIMPLE SO A CALCULATOR SHOULD NOT BE REQUIRED, SHOW YOUR WORKING AND USE…
QUESTION 7 A trihybrid individual with the genotype AaDdEe is testcrossed with an aaddee individual. The resulting offspring are as follows: ADe 880 aDE 67 AdE 45 ade 4 ADE 3 aDe 57 Ade 57 adE 887 Total = 2000 a) Determine the allele arrangement and gene order in the trihybrid parent. Give your answer using the PQr/pqR notation. b) Draw a chromosome map for these genes. Give your map distances to two decimal places. (Use underline or underscore (_) to draw the line for the map)
QUESTION 3 Linkage disequilibrium is defined by which of the following? O Positions in the genome where people vary by a single nucleotide base O The occurrence of two alleles in the repulsion configuration O The probability that two genes are linked O Crossing over that occurs between two genes that are located close to each other O The nonrandom association between alleles in a haplotype QUESTION 4 Red-green color blindness is a human recessive X-linked disorder. A young man with a 47, XXY karyotype (Klinefelter syndrome) is colorblind. His mother and father have normal color vision, but his mother has a father who is colorblind Did the nondisjunction event that gave rise to the young man with Klinefelter syndrome happen in the mother, the father or is it impossible to tell (assume that no crossing over took place in prophase I of meiosis)? a. Mother b. Father c. Impossible to tell Did this nondisjunction happen during Meiosis I, Meiosis II, or is it impossible to tell? a. Meiosis I…
I need help answering the following question from the following article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762880/ Science and Society: In 1966, Stanley Gartler presented his findings at an international conference- 18 of the most commonly used cell lines all contained the same genetic marker, G6PD-A. This gene allele is found almost exclusively in African Americans. This was a problem because a large number of these cell lines, excluding HeLa cells, were established from Caucasian individuals. He suggested that these lines were in fact contaminated with HeLa cells, which proliferate at extreme rates and were used in labs all over the world. What would you expect was the response of those scientists using the “contaminated” cell lines? Do you think this marker is enough to establish this contamination?
QUESTION 2 A researcher crosses mice with brown eyes and short tails, and the F1 progeny were recovered in the following numbers and phenotypic classes: F1: 32 apricot, short : 30 brown, long : 139 brown, short : 9 apricot, long You know the genes encoding these traits are autosomal, completely dominant and assort independently. You want to use a chi-square test to analyse these results. a) Give the expected number of individuals in the "brown, short" class. b) What is your null hypothesis for the chi-square test? c) You obtain a value of 8.59 for the chi-square test. What conclusion can you make from the results of the chi-square test? d) Making use of the appropriate genetic convention for naming alleles, give the genotype of any of the progeny in the "apricot, short" class. df 0.995 0.975 0.9 0.5 0.1 0.05* 0.025 0.01 0.005 1 0.000 0.000 0.016 0.455 2.706 3.841 5.024 6.635 7.879 2 0.010 0.051 0.211 1.386 4.605 5.991 7.378 9.210 10.597 0.072 0.216 0.584 2.366 6.251 7.815 9.348 11.345…
Question 8.In a population of 235 individuals, it was observed that 200 were found to be (AA), 30 were found to be (Aa), & 5 were found to be (aa). A) Find the expected number of individuals for each of the genotypes observed. B) Conduct a X2analysis to determine if the alleles (A) & (a) are in Hardy-Weinberg equilibrium (use the probability chart below) Hint: use the chi square formula and the table below
Question 1 The possession of one of two types of earlobes (hanging or attached) is sometimes used to study the inheritance of characteristics in humans. The pedigree shows the different types of earlobes present in three generations. KEY male with hanging earlobes II female with hanging earlobes male with attached earlobes female with attached earlobes III Discuss the type of inheritance shown in the pedigree. In your answer, include reference to the alleles involved using standard notation.
Question 10 of 18 Attempt 10 Suppose a geneticist uses a three-point testeross to map three recessive, linked hummingbird wing-shape mutations called tk, f, and s, where tk is associated with thick wings, f is associated with flat wings, and s is associated with sharp wings. He first crosses homozygous sharp birds to homozygous thick, flat birds. Next, he testcrosses the Fi progeny to thick, flat, sharp birds. He obtained the results shown. Given this data, label the progeny phenotypic classes as either parental, single crossover (SCO), or double crossover (DCO) recombinant types. Each label may be used multiple times. Two classes have already been filled in. Phenotype Number Recombinant type sharp 819 Answer Bank thick, flat 821 SCO DCO flat 183 parental thick, sharp 169 SCO thick 6. flat, sharp thick, flat, sharp 28 SCO wild type 26
Question 6 Review non Mendelian genetics. Match the term and its description. Each term can only be used once. the phenotype of F1 hybrids is somewhere between the phenotypes of the two parental varieties | Choose | two dominant alleles affect the phenotype in separate and distinguishable ways | Choose | Most genes exist in populations in more than two allelic forms | Choose | Most genes have multiple phenotypic effects [ Choose J multiple genes independently affect a single trait | Choose | expression of a gene at one locus alters the phenotypic expression of a gene at a second locus [ Choose J > > > >
Question 1 Given that the passing of alleles into gametes is random, if we observe one gamete (egg or sperm) of an individual at a specific gene/locus: What is the probability that the allele in that gamete is the one from the father of the individual making the gametes? 2. What is the probability that the allele in that gamete is the one from the mother of the individual making the gametes?

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