Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 4.2P
Related questions
Question
100%
Based on the BLASTp and Reciprocal hit analysis is mus musculus a true ortholog for the human fgfr3 gene?
![First BLASTP
Mastp of M. Musculus with human FGFR3 (NP_075254.1) as the query.
TOP HIT: fibroblast growth factor receptor 3 isoform 5 (Mus musculur)
Sequence ID: NP_001345966.1
Query 172 VRFRCPAAGNPTPSISWLK-
VFC + PIWLK
a
DG YTC+ NG
Query 1
Sbjct
159
Query 61 VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVY
VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVY
VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVY
277
Sbjct 219
229
KVSLESNASMSSNTPLVRIAR 330
+VSLESN+SM+SNTPLVRIAR
284
Query 121 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
Query 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL
L G
Sbjct 279
338
Sbjet 230 LVVAAVILCRLRSPPKKGL- -GSPTVHKVSRFPLKROVSLESNSSMNSNTPLVRIAR
390
LSSGEGP LANVSELELPADPKWELSR RLTLGKPLGEGCFGOVVMAEAIGIDKDR AKP
344
450
Query 331 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGOVVMAEAIGIDKDRAAKP
Query 181 CLAGNSIGFSHHSAWLVVL PAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRL 240
CLAGNSIGFSHHSAWLVVL PAEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRL
Sbjet 285 LSSGEGPVLANVSELELPADPKWELSRTALTLGKPLGEGCFGQVVMAEAIGIDKDRTAKP
Sbjct 339 CLAGNSIGFSHHSAWLVVL PAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRL 398
Query 391 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN
VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN
Query 241
RSPPKKGLGSPTVHKVSRFPLKROVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELE 300
Sbjct 345 VTVAVIMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN 404
RSPPKKGLGSPTVHK+SRFPLKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELE
Sbjct 399 RSPPKKGLGSPTVHKISRFPLKROVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELE 458
Query 451 LREFLRARRPPGLDYSFDTCKPPEEOLTFKDLVSCAYOVARGHEYLASOKCIHRDLAARN 510
LREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCAYOVARGMEYLASOKCIHRDLAARN
Query 301 LPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKD 360
Sbjct 405 LREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARN 464
LPADPKWELSR RLTLGKPLGEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKD
Query 511 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHOSDVWSFGV 570
Sbjct 459 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFORVYTHOSDVWSFGV
Sbjet 465 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFORVYTHOSDVWSFGV 524
Query 361 LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPGMDYS 420
Query 571 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMOKPANCTHDLYMIMRECWHAAPSORPTFK 630
LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYS
Sbjct 519 LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPGLDYS 578
Sujet 525 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSORPTFK 584 Query 421 FDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 480
A
9
+G+
Sbjct 113 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTOKELEVLSLHNVT
Query 220
Sbjct 173 FEDAGEYTCLAGNSIGFSHHSAWLWL-AEEELMETDEAGSVYAGVLSYGVVFFLFI
PSDRGNYTCWVENKFGSIROTYTLDVLERSHRPILOAGLPANQT-AVLGSDVEFHCKV
L VL
▬
10
NGREFRGEHRIGGINLR 100WS-LVMESVV 219
++L+V
+G
172
G+P V +
Q Search
LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMOKPA CTHDLYMIMRECWHA PSORPTFK
VL VF+
11
12
13
14
15
Blastp of humans with M. Musculus top hit (NP_001345966.1) as query.
TOP HIT: fibroblast growth factor receptor 3 isoform 1 precursor [Homo sapiens]
Sequence ID: NP_000133.1
16
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESV 60
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESV
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHOQWSLVMESV 218
En r DECAIT VOI VECAVOVADCUEVI ACAVATUDDI AADAVI UTCOAUMUTADcri
120
278
180
12:27 PM
12/3/2023](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4c5addd0-3107-4aed-8c6b-6b5b2f9fadb0%2F7650b685-068d-4129-b4ec-92bb6169c588%2Fzye5uak_processed.jpeg&w=3840&q=75)
Transcribed Image Text:First BLASTP
Mastp of M. Musculus with human FGFR3 (NP_075254.1) as the query.
TOP HIT: fibroblast growth factor receptor 3 isoform 5 (Mus musculur)
Sequence ID: NP_001345966.1
Query 172 VRFRCPAAGNPTPSISWLK-
VFC + PIWLK
a
DG YTC+ NG
Query 1
Sbjct
159
Query 61 VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVY
VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTA+LGSDVEFHCKVY
VPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVY
277
Sbjct 219
229
KVSLESNASMSSNTPLVRIAR 330
+VSLESN+SM+SNTPLVRIAR
284
Query 121 SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
SDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYT
Query 278 YSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVL
L G
Sbjct 279
338
Sbjet 230 LVVAAVILCRLRSPPKKGL- -GSPTVHKVSRFPLKROVSLESNSSMNSNTPLVRIAR
390
LSSGEGP LANVSELELPADPKWELSR RLTLGKPLGEGCFGOVVMAEAIGIDKDR AKP
344
450
Query 331 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGOVVMAEAIGIDKDRAAKP
Query 181 CLAGNSIGFSHHSAWLVVL PAEEELMETDEAGSVYAGVLSYGVVFFLFILVVAAVILCRL 240
CLAGNSIGFSHHSAWLVVL PAEEEL+E DEAGSVYAG+LSYGV FFLFILVVAAV LCRL
Sbjet 285 LSSGEGPVLANVSELELPADPKWELSRTALTLGKPLGEGCFGQVVMAEAIGIDKDRTAKP
Sbjct 339 CLAGNSIGFSHHSAWLVVL PAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRL 398
Query 391 VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN
VTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN
Query 241
RSPPKKGLGSPTVHKVSRFPLKROVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSELE 300
Sbjct 345 VTVAVIMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGN 404
RSPPKKGLGSPTVHK+SRFPLKROVSLESN+SM+SNTPLVRIARLSSGEGP LANVSELE
Sbjct 399 RSPPKKGLGSPTVHKISRFPLKROVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELE 458
Query 451 LREFLRARRPPGLDYSFDTCKPPEEOLTFKDLVSCAYOVARGHEYLASOKCIHRDLAARN 510
LREFLRARRPPG+DYSFD C+ PEEQLT KDLVSCAYOVARGMEYLASOKCIHRDLAARN
Query 301 LPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKD 360
Sbjct 405 LREFLRARRPPGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARN 464
LPADPKWELSR RLTLGKPLGEGCFGQVVMAEAIGIDKDR AKPVTVAVKMLKDDATDKD
Query 511 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHOSDVWSFGV 570
Sbjct 459 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518
VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFORVYTHOSDVWSFGV
Sbjet 465 VLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFORVYTHOSDVWSFGV 524
Query 361 LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPGMDYS 420
Query 571 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMOKPANCTHDLYMIMRECWHAAPSORPTFK 630
LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPG+DYS
Sbjct 519 LSDLVSEMEMMKMIGKHKNIINLLGACTOGGPLYVLVEYAAKGNLREFLRARRPPGLDYS 578
Sujet 525 LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSORPTFK 584 Query 421 FDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGL 480
A
9
+G+
Sbjct 113 VEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTOKELEVLSLHNVT
Query 220
Sbjct 173 FEDAGEYTCLAGNSIGFSHHSAWLWL-AEEELMETDEAGSVYAGVLSYGVVFFLFI
PSDRGNYTCWVENKFGSIROTYTLDVLERSHRPILOAGLPANQT-AVLGSDVEFHCKV
L VL
▬
10
NGREFRGEHRIGGINLR 100WS-LVMESVV 219
++L+V
+G
172
G+P V +
Q Search
LLWEIFTLGGSPYPGIPVEELFKLLKEGHRMOKPA CTHDLYMIMRECWHA PSORPTFK
VL VF+
11
12
13
14
15
Blastp of humans with M. Musculus top hit (NP_001345966.1) as query.
TOP HIT: fibroblast growth factor receptor 3 isoform 1 precursor [Homo sapiens]
Sequence ID: NP_000133.1
16
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESV 60
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG+EFRGEHRIGGIKLRHQQWSLVMESV
MDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHOQWSLVMESV 218
En r DECAIT VOI VECAVOVADCUEVI ACAVATUDDI AADAVI UTCOAUMUTADcri
120
278
180
12:27 PM
12/3/2023
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