Given the following information, calculate the physiological ΔG of the isocitrate dehydrogenase reaction at 25°C and pH 7.0: [NAD+]/[NADH] = 8, [α-ketoglutarate] = 0.1 mM, and [isocitrate] = 0.02 mM. Assume standard conditions for CO2 (ΔG°′ is given in Table). Is this reaction a likely site for metabolic control? AG'(kJ • mol-!)AGReactionEnzyme(kJ • mol-)1Citrate synthase-31.5Negative2.Aconitase-5-03Isocitrate dehydrogenase-21Negative4a-Ketoglutarate dehydrogenase-33NegativeSuccinyl-CoA synthetase-2.1-0Succinate dehydrogenase+6-07Fumarase-3.4-08Malate dehydrogenase+29.7-0

Gibbs free energy or Free energy is a potential of thermodynamics that helps in calculating…

AG' (kJ • mol-!) AG Reaction Enzyme (kJ • mol-) 1 Citrate synthase -31.5 Negative 2. Aconitase -5 -0 3 Isocitrate dehydrogenase -21 Negative 4 a-Ketoglutarate dehydrogenase -33 Negative Succinyl-CoA synthetase -2.1 -0 Succinate dehydrogenase +6 -0 7 Fumarase -3.4 -0 8 Malate dehydrogenase +29.7 -0

AG' (kJ • mol-!) AG Reaction Enzyme (kJ • mol-) 1 Citrate synthase -31.5 Negative 2. Aconitase -5 -0 3 Isocitrate dehydrogenase -21 Negative 4 a-Ketoglutarate dehydrogenase -33 Negative Succinyl-CoA synthetase -2.1 -0 Succinate dehydrogenase +6 -0 7 Fumarase -3.4 -0 8 Malate dehydrogenase +29.7 -0

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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